Hematopoietic stem cell transplantation for autoimmune diseases: What have we learned?

被引：61
|
作者：
Burt, Richard K. [1 ]
Testor, Alessandro [1 ]
Craig, Robert [2 ]
Cohen, Bruce [3 ]
Suffit, Robert [3 ]
Barr, Walter [4 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Immunotherapy, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Gastroenterol, Chicago, IL 60611 USA
[3] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA
[4] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Rheumatol, Chicago, IL 60611 USA
来源：
JOURNAL OF AUTOIMMUNITY | 2008年 / 30卷 / 03期
关键词：
hematopoietic stem cell transplantation (HSCT); autologous HSCT; animal models; human trials;
D O I：
10.1016/j.jaut.2007.12.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Numerous individuals and institutions throughout the world have contributed to the development of hematopoietic stem cell transplantation (HSCT) for autoimmune diseases. In this review, we will summarize what we have learned at our own institution (Northwestern University), and how it has guided our therapy. An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases. (C) 2008 Published by Elsevier Ltd.
引用
收藏
页码：116 / 120
页数：5
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