Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor

被引:18
作者
Ayala, Juan Carlos [1 ]
Grismaldo, Adriana [2 ]
Sequeda-Castaneda, Luis Gonzalo [3 ]
Aristizabal-Pachon, Andres Felipe [2 ]
Morales, Ludis [2 ]
机构
[1] Pontificia Univ Javeriana, Fac Sci, Bogota 110231, Colombia
[2] Pontificia Univ Javeriana, Fac Sci, Dept Nutr & Biochem, Bogota 110231, Colombia
[3] Pontificia Univ Javeriana, Fac Sci, Dept Chem, Bogota 110231, Colombia
关键词
reactive oxygen species; critically ill; sepsis; survival; FRAILTY; MECHANISMS; SARCOPENIA; CONSENSUS; DISEASES; SEPSIS;
D O I
10.3390/antiox10121912
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell growth and homeostasis, as well as in response to metabolic adaptations, autophagy, immunity, differentiation and cell aging, the latter of which is an important characteristic in acute and chronic pathologies. Thus, the measurement of ROS levels of critically ill patients, upon admission, enables a prediction not only of the severity of the inflammatory response, but also of its subsequent potential outcome. The aim of this study was to measure the levels of mitochondrial ROS (superoxide anion) in the peripheral blood lymphocytes within 24 h of admission and correlate them with survival at one year after ICU and hospital discharge. We designed an observational prospective study in 51 critical care patients, in which clinical variables and ROS production were identified and correlated with mortality at 12 months post-ICU hospitalization. Oxidative stress levels, measured as DHE fluorescence, show a positive correlation with increased long-term mortality. In ICU patients the major determinant of survival is oxidative stress, which determines inflammation and outlines the cellular response to inflammatory stimuli.
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页数:10
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