Satellite Glial Cells: Morphology, functional heterogeneity, and role in pain

被引：18

作者：

Andreeva, Daria ^{[1
]}

Murashova, Lada ^{[1
]}

Burzak, Nikita ^{[1
]}

Dyachuk, Vyacheslav ^{[1
]}

机构：

[1] Almazov Fed Med Res Ctr, St Petersburg, Russia

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

关键词：

satellite glial cells; chronic pain; pain conditions; nerve injury; heterogeneity; DORSAL-ROOT GANGLIA; SENSORY GANGLIA; GAP-JUNCTIONS; CENTRAL SENSITIZATION; TRIGEMINAL GANGLIA; NEUROPATHIC PAIN; SPINAL GANGLIA; P2X7; RECEPTORS; FINE-STRUCTURE; IMMUNE CELLS;

D O I：

10.3389/fncel.2022.1019449

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurons in the somatic, sympathetic, and parasympathetic ganglia are surrounded by envelopes consisting of satellite glial cells (SGCs). Recently, it has become clear that SGCs are highly altered after nerve injury, which influences neuronal excitability and, consequently, the development and maintenance of pain in different animal models of chronic pain. However, the exact mechanism underlying chronic pain is not fully understood yet because it is assumed that SGCs in different ganglia share many common peculiarities, making the process complex. Here, we review recent data on morphological and functional heterogeneity and changes in SGCs in various pain conditions and their role in response to injury. More research is required to decipher the role of SGCs in diseases, such as chronic pain, neuropathology, and neurodegenerative diseases.

引用

页数：8

共 105 条

[71]

Sakuma Eisuke, 2001, Acta Anatomica Nipponica, V76, P297

[72] Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles [J].