Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2) H activation and C(sp3)-H amination

被引：12
|
作者：
Song, Liangliang [1 ]
Tian, Guilong [1 ]
Van der Eycken, Johan [2 ]
Van der Eycken, Erik V. [1 ,3 ]
机构：
[1] Katholieke Univ Leuven, Dept Chem, LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[2] Univ Ghent, Dept Organ & Macromol Chem, Lab Organ & Bioorgan Synth, Krijgslaan 281 S4, B-9000 Ghent, Belgium
[3] Peoples Friendship Univ Russia, RUDN Univ, Miklukho Maklaya St 6, Moscow, Russia
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷
关键词：
annulation; C-H activation; rhodium; acrylamide; heterocycles; CONCISE SYNTHESIS; DIRECTING GROUP; CAMPTOTHECIN; ALKYNES; AMIDE; FUNCTIONALIZATION; ALKENES;
D O I：
10.3762/bjoc.15.52
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp(2))-H activation and C(sp(3))-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.
引用
收藏
页码：571 / 576
页数：6
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