Validation and application of an HPLC method for determination of di (2-ethylhexyl) phthalate and mono (2-ethylhexyl) phthalate in liver samples

被引：14
|
作者：
Sircar, Debajit [2 ]
Albazi, Sargon J. [1 ]
Atallah, Yousef [2 ]
Pizzi, William [1 ]
机构：
[1] NE Illinois Univ, Dept Psychol, Chicago, IL 60625 USA
[2] NE Illinois Univ, Dept Chem, Chicago, IL 60625 USA
来源：
JOURNAL OF CHROMATOGRAPHIC SCIENCE | 2008年 / 46卷 / 07期
关键词：
D O I：
10.1093/chromsci/46.7.627
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A reversed-phase gradient elution, UV detection method is developed for the simultaneous determination of mono (2-ethylhexyl) phthalate [MEHP] and di (2-ethylhexyl) phthalate [DEHP] in tissue samples. The method is validated with respect to extraction recovery, inter and intra-day precision, linearity of response, detect ability, and specificity. The validated method has been successfully applied to the study of DEHP and MEHP in liver, kidney, testis, brain, and plasma samples from rat.
引用
收藏
页码：627 / 631
页数：5
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