Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation

被引：9
|
作者：
Lazaro-Navarro, Juan [1 ,2 ]
Pimentel-Gutierrez, Helia Judith [1 ,2 ]
Gauert, Anton [1 ,2 ]
Hagemann, Anja I. H. [1 ]
Eisenschmid, Jassi [3 ,4 ]
Goekbuget, Nicola [2 ,4 ]
Vick, Binje [2 ,5 ]
Jeremias, Irmela [2 ,5 ]
Seyfried, Felix [6 ]
Meyer, Luder Hinrich [6 ]
Debatin, Klaus-Michael [6 ]
Richer, Kathrin [7 ]
Bultman, Miriam [7 ]
Neumann, Martin [2 ,7 ]
Hanzelmann, Sonja [2 ]
Serve, Hubert [2 ,3 ,4 ]
Astrahantseff, Kathy [1 ]
Rieger, Michael A. [2 ,3 ,4 ]
Eckert, Cornelia [1 ,2 ]
Baldus, Claudia D. [2 ,7 ]
Bastian, Lorenz [2 ,7 ]
机构：
[1] Charit Univ med Berlin, Dept Pediat Oncol Hematol, Berlin, Germany
[2] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany
[3] Frankfurt Canc Inst, Frankfurt, Germany
[4] Goethe Univ Hosp Frankfurt, Dept Med Hematol Oncol, Frankfurt, Germany
[5] Helmholtz Ctr Munich German Ctr Environm Hlth HMG, Dept Apoptosis Hematopoiet Stem Cells, Munich, Germany
[6] Univ Ulm, Dept Pediat & Adolescent Med, Med Ctr, Ulm, Germany
[7] Univ Med Ctr Schleswig Holstein, Med Dept 2, Hematol Oncol, Campus Kiel, Kiel, Germany
来源：
BLOOD ADVANCES | 2021年 / 5卷 / 24期
关键词：
BCL-2; DEPENDENCE; APOPTOSIS; CK2; ACTIVATION; GENOMICS;
D O I：
10.1182/bloodadvances.2021004513
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：5501 / 5506
页数：6
相关论文
共 50 条
  • [21] Hydroquinone-selected chronic myelogenous leukemia cells are sensitive to chloroquine-induced cytotoxicity via MCL1 suppression and glycolysis inhibition
    Chiou, Jing-Ting
    Lee, Yuan-Chin
    Chang, Long-Sen
    BIOCHEMICAL PHARMACOLOGY, 2023, 218
  • [22] AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia
    Barbetti, V.
    Tusa, I.
    Cipolleschi, M. G.
    Rovida, E.
    Dello Sbarba, P.
    CELL DEATH & DISEASE, 2013, 4 : e536 - e536
  • [23] Inhibiting the expression of anti-apoptotic genes BCL2L1 and MCL1, and apoptosis induction in glioblastoma cells by microRNA-342
    Ghaemi, Shokoofeh
    Arefian, Ehsan
    Valojerdi, Rezvan Rezazadeh
    Soleimani, Masoud
    Moradimotlagh, Atieh
    Adegani, Fatemeh Jamshidi
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 121
  • [24] A phase 1/2 study of mini-hyper-CVD plus venetoclax in patients with relapsed/refractory acute lymphoblastic leukemia
    Short, Nicholas J.
    Jabbour, Elias
    Jain, Nitin
    Senapati, Jayastu
    Nasr, Lewis
    Haddad, Fadi G.
    Li, Zhenhua
    Hsiao, Yu-Chih
    Yang, Jun J.
    Pemmaraju, Naveen
    Ohanian, Maro
    Wierda, William G.
    Montalban-Bravo, Guillermo
    Borthakur, Gautam
    Han, Lina
    Xiao, Lianchun
    Huang, Xuelin
    Abramova, Regina
    Zhao, Min
    Garris, Rebecca
    Konopleva, Marina
    Ravandi, Farhad
    Kantarjian, Hagop
    BLOOD ADVANCES, 2024, 8 (04) : 909 - 915
  • [25] Casein kinase 1α inhibits p53 downstream of MDM2-mediated autophagy and apoptosis in acute myeloid leukemia
    Xu, Wanling
    Huang, Ziyang
    Gan, Yifeng
    Chen, Rongrong
    Huang, Yisha
    Xue, Bin
    Jiang, Songfu
    Yu, Zhijie
    Yu, Kang
    Zhang, Shenghui
    ONCOLOGY REPORTS, 2020, 44 (05) : 1895 - 1904
  • [26] BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells
    Chiou, Jing-Ting
    Lee, Yuan-Chin
    Wang, Liang-Jun
    Chang, Long-Sen
    CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 361
  • [27] Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation
    Tao, Yan-Fang
    Li, Zhi-Heng
    Du, Wei-wei
    Xu, Li-xiao
    Ren, Jun-Li
    Li, Xiao-Lu
    Fang, Fang
    Xie, Yi
    Wu, Yi
    Feng, Xing
    Wang, Jian
    He, Wei-Qi
    Hu, Shao-Yan
    Lu, Jun
    Pan, Jian
    ONCOLOGY REPORTS, 2017, 37 (03) : 1419 - 1429
  • [28] Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells
    Chiou, Jing-Ting
    Lee, Yuan-Chin
    Huang, Chia-Hui
    Wang, Liang-Jun
    Shi, Yi-Jun
    Chang, Long-Sen
    BIOCHEMICAL PHARMACOLOGY, 2021, 188
  • [29] Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1
    Fiorcari, Stefania
    Maffei, Rossana
    Atene, Claudio Giacinto
    Mesini, Nicolo
    Maccaferri, Monica
    Leonardi, Giovanna
    Martinelli, Silvia
    Paolini, Ambra
    Nasillo, Vincenzo
    Debbia, Giulia
    Potenza, Leonardo
    Luppi, Mario
    Marasca, Roberto
    FRONTIERS IN ONCOLOGY, 2022, 11
  • [30] Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition
    Carter, Bing Z.
    Mak, Po Yee
    Tao, Wenjing
    Warmoes, Marc
    Lorenzi, Philip L.
    Mak, Duncan
    Ruvolo, Vivian
    Tan, Lin
    Cidado, Justin
    Drew, Lisa
    Andreeff, Michael
    HAEMATOLOGICA, 2022, 107 (01) : 58 - 76
12345