Stereoselective Approach for the Synthesis of 2-epi-Hyacinthacine A2, (-)-7a-epi-Hyacinthacine A1, 1-Deoxy-d-altro-homonojirimycin, and Some Pyrrolidine Iminosugars

被引：3
作者：
Chirke, Sahadev S.
Rao, Batchu Venkateswara [1 ]
机构：
[1] Acad Sci & Innovat Res, New Delhi, India
来源：
SYNLETT | 2016年 / 27卷 / 16期
关键词：
azasugar; Grignard addition; glycosidase; glycosyltransferase; hyacianthacine; 5-exo-tet epoxide ring opening; GLYCOSIDASE INHIBITION; BIOLOGICAL EVALUATION; (-)-HYACINTHACINE A1; ORGANIC-SYNTHESIS; ANALOGS; DERIVATIVES; ALKALOIDS; ALDOLASE; IMINO; PYRROLIZIDINES;
D O I：
10.1055/s-0035-1562782
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A divergent approach has been developed for the synthesis of some important iminosugars by stereoselective allylation of the lyxosylamine derived from d-lyxose and intramolecular 5-exo-tet ring opening of the epoxide. The strategy described in this paper will be useful for the synthesis of some other biologically active iminosugars for the drug-discovery program.
引用
收藏
页码：2391 / 2395
页数：5
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