The myosin activator: is another step forward in heart failure therapy?

被引：2

作者：

Abete, Raffaele ^{[1
]}

Iacovoni, Attilio ^{[1
]}

Senni, Michele ^{[1
]}

机构：

[1] ASST Papa Giovanni XXIII, Dipartimento Cardiovasc, Bergamo, Italy

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2021年 / 23卷 / 0E期

关键词：

Heart failure; Selective cardiac myosin activators; Cardiac contractility; INCREASE CONTRACTILITY; OMECAMTIV MECARBIL;

D O I：

10.1093/eurheartj/suab114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Selective cardiac myosin activators constitute a new class of drugs capable of increasing cardiac contractility independently of intracellular calcium concentrations. In the GALACTIC-HF study, the first of this class of molecules, omecamtiv mercabil, was compared with the standard of care according to current guidelines, showing a significant reduction in the composite endpoint of first episode of heart failure or mortality due to cardiovascular causes in patients exposed to treatment compared with placebo. In particular, the effect was more pronounced for decreasing ejection fraction values, suggesting a potential further benefit of selective cardiac myosin activators in this category of patients.

引用

页码：E151 / E155

页数：5

共 7 条

[1] Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure [J].

Malik, Fady I. ;

Hartman, James J. ;

Elias, Kathleen A. ;

Morgan, Bradley P. ;

Rodriguez, Hector ;

Brejc, Katjusa ;

Anderson, Robert L. ;

Sueoka, Sandra H. ;

Lee, Kenneth H. ;

Finer, Jeffrey T. ;

Sakowicz, Roman ;

Baliga, Ramesh ;

Cox, David R. ;

Garard, Marc ;

Godinez, Guillermo ;

Kawas, Raja ;

Kraynack, Erica ;

Lenzi, David ;

Lu, Pu Ping ;

Muci, Alexander ;

Niu, Congrong ;

Qian, Xiangping ;

Pierce, Daniel W. ;

Pokrovskii, Maria ;

Suehiro, Ion ;

Sylvester, Sheila ;

Tochimoto, Todd ;

Valdez, Corey ;

Wang, Wenyue ;

Katori, Tatsuo ;

Kass, David A. ;

Shen, You-Tang ;

Vatner, Stephen F. ;

Morgans, David J. .

SCIENCE, 2011, 331 (6023) :1439-1443

[2] Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil [J].

Planelles-Herrero, Vicente J. ;

Hartman, James J. ;

Robert-Paganin, Julien ;

Malik, Fady I. ;

Houdusse, Anne .

NATURE COMMUNICATIONS, 2017, 8

[3] Cardiac Calcitropes, Myotropes, and Mitotropes JACC Review Topic of the Week [J].

Psotka, Mitchell A. ;

Gottlieb, Stephen S. ;

Francis, Gary S. ;

Allen, Larry A. ;

Teerlink, John R. ;

Adams, Kirkwood F., Jr. ;

Rosano, Giuseppe M. G. ;

Lancellotti, Patrizio .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (18) :2345-2353

[4] Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF [J].

Teerlink, John R. ;

Diaz, Rafael ;

Felker, G. Michael ;

McMurray, John J., V ;

Metra, Marco ;

Solomon, Scott D. ;

Biering-Sorensen, Tor ;

Boehm, Michael ;

Bonderman, Diana ;

Fang, James C. ;

Lanfear, David E. ;

Lund, Mayanna ;

Momomura, Shin-Ichi ;

O'Meara, Eileen ;

Ponikowski, Piotr ;

Spinar, Jindrich ;

Flores-Arredondo, Jose H. ;

Claggett, Brian L. ;

Heitner, Stephen B. ;

Kupfer, Stuart ;

Abbasi, Siddique A. ;

Malik, Fady, I .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (02) :97-108

[5] Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial [J].

Teerlink, John R. ;

Felker, G. Michael ;

McMurray, John J. V. ;

Solomon, Scott D. ;

Adams, Kirkwood F., Jr. ;

Cleland, John G. F. ;

Ezekowitz, Justin A. ;

Goudev, Assen ;

Macdonald, Peter ;

Metra, Marco ;

Mitrovic, Veselin ;

Ponikowski, Piotr ;

Serpytis, Pranas ;

Spinar, Jindrich ;

Tomcsanyi, Janos ;

Vandekerckhove, Hans J. ;

Voors, Adriaan A. ;

Monsalvo, Maria Laura ;

Johnston, James ;

Malik, Fady I. ;

Honarpour, Narimon .

LANCET, 2016, 388 (10062) :2895-2903

[6] Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure The ATOMIC-AHF Study [J].

Teerlink, John R. ;

Felker, G. Michael ;

McMurray, John J. V. ;

Ponikowski, Piotr ;

Metra, Marco ;

Filippatos, Gerasimos S. ;

Ezekowitz, Justin A. ;

Dickstein, Kenneth ;

Cleland, John G. F. ;

Kim, Jae B. ;

Lei, Lei ;

Knusel, Beat ;

Wolff, Andrew A. ;

Malik, Fady I. ;

Wasserman, Scott M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (12) :1444-1455

[7] Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study [J].

Teerlink, John R. ;

Clarke, Cyril P. ;

Saikali, Khalil G. ;

Lee, Jacqueline H. ;

Chen, Michael M. ;

Escandon, Rafael D. ;

Elliott, Lyndsey ;

Bee, Rachel ;

Habibzadeh, Mohammad Reza ;

Goldman, Jonathan H. ;

Schiller, Nelson B. ;

Malik, Fady I. ;

Wolff, Andrew A. .

LANCET, 2011, 378 (9792) :667-675

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