Nickel-Catalyzed Selective Conversion of Two Different Aldehydes to Cross-Coupled Esters

被引：95

作者：

Hoshimoto, Yoichi ^{[1
]}

Ohashi, Masato ^{[1
,2
]}

Ogoshi, Sensuke ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 13期

关键词：

TISHCHENKO REACTION; BOND FORMATION; HYDROACYLATION; DIMERIZATION; COMPLEXES; DECARBONYLATION; MECHANISM; KETONES; ALKYNES;

D O I：

10.1021/ja109908x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of a Ni(0)/NHC catalyst, an equimolar mixture of aliphatic and aryl aldehydes can be employed to selectively yield a single cross-coupled ester. This reaction can be applied to a variety of aliphatic (1 degrees, 2 degrees, cyc-2 degrees, and 3 degrees) and aryl aldehyde combinations. The reaction represents 100% atom efficiency and generates no waste. Mechanistic studies have revealed that the striking feature of the reaction is the simultaneous coordination of two aldehydes to Ni(0).

引用

页码：4668 / 4671

页数：4

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