The Origin of Cholesterol's Condensing Effect

被引：48

作者：

Daly, Trevor A. ^{[1
]}

Wang, Minghui ^{[1
]}

Regen, Steven L. ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

LANGMUIR | 2011年 / 27卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PHASE; MIXTURES; MODEL; DPPC;

D O I：

10.1021/la105039q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The condensing effect of cholesterol on fluid bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine has been compared with that of dihydrocholesterol and coprostanol by means of nearest-neighhor recognition measurements. Whereas dihydrocholesterol exhibits a condensing power that is equivalent to that of cholesterol, the action of coprostanol is significantly weaker. These results provide strong support for a template mechanism of condensation and argue against an umbrella mechanism.

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收藏

页码：2159 / 2161

页数：3

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