Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review

被引:22
作者
Gomez, Nancy [1 ]
James, Victoria [2 ]
Onion, David [1 ]
Fairclough, Lucy C. [1 ]
机构
[1] Univ Nottingham, Sch Life Sci, Life Sci Bldg, Nottingham NG7 2RD, England
[2] Univ Nottingham, Sch Vet Med & Sci, Nottingham NG7 2UH, England
关键词
COPD; Chronic Obstructive Pulmonary Disease; Extracellular vesicles; Exovesicles; CIRCULATING ENDOTHELIAL MICROPARTICLES; CIGARETTE-SMOKE; POTENTIAL BIOMARKER; IGG SENSITIZATION; EXOSOMES; EMPHYSEMA; CELLS; EXACERBATION; DESTRUCTION; DYSFUNCTION;
D O I
10.1186/s12931-022-01984-0
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important intercellular communication mediators released by cells into their extracellular environment with the capacity to transfer biological signals. EVs involved in COPD hold great potential to understand disease pathogenesis and identify important biomarkers. This systematic review aims to examine all available research on EVs in the pathogenesis and diagnosis of COPD to identify existing knowledge and support further research within the field. Methods Publications were searched using PubMed and EMBASE with the search terms (Exosomes or extracellular vesicles or microvesicles or microparticles or ectosomes) AND (chronic obstructive pulmonary disease or COPD or emphysema or bronchitis). Results Initial search yielded 512 papers of which 142 were manually selected for review and 43 were eligible for analyses. The studies were divided into groups according to the role of EVs in pathogenesis, EV origin and cargo, their role in COPD exacerbations and their diagnostic utility. EVs were found to be involved in the mechanism of pathogenesis of COPD, derived from various cell types, as well as containing modified levels of miRNAs. EVs also varied according to the pathophysiological status of disease, therefore presenting a possible method for COPD diagnosis and progress monitoring. Conclusion The current findings show the limited but good quality research looking at the role of EVs in COPD, demonstrating the need for more studies to better define and provide further insight into the functional characteristics of EV in COPD pathogenesis.
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页数:20
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共 76 条
  • [61] Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility
    Takahashi, Toru
    Kobayashi, Seiichi
    Fujino, Naoya
    Suzuki, Takaya
    Ota, Chiharu
    He, Mei
    Yamada, Mitsuhiro
    Suzuki, Satoshi
    Yanai, Masaru
    Kurosawa, Shin
    Yamaya, Mutsuo
    Kubo, Hiroshi
    [J]. THORAX, 2012, 67 (12) : 1067 - 1074
  • [62] Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation
    Tan, Dino B. A.
    Armitage, Jesse
    Teo, Teck-Hui
    Ong, Nathanael E.
    Shin, Heewoong
    Moodley, Yuben P.
    [J]. RESPIRATORY MEDICINE, 2017, 132 : 261 - 264
  • [63] COPD and the response of the lung to tobacco smoke exposure
    Taylor, John D.
    [J]. PULMONARY PHARMACOLOGY & THERAPEUTICS, 2010, 23 (05) : 376 - 383
  • [64] Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
    Thery, Clotilde
    Witwer, Kenneth W.
    Aikawa, Elena
    Jose Alcaraz, Maria
    Anderson, Johnathon D.
    Andriantsitohaina, Ramaroson
    Antoniou, Anna
    Arab, Tanina
    Archer, Fabienne
    Atkin-Smith, Georgia K.
    Ayre, D. Craig
    Bach, Jean-Marie
    Bachurski, Daniel
    Baharvand, Hossein
    Balaj, Leonora
    Baldacchino, Shawn
    Bauer, Natalie N.
    Baxter, Amy A.
    Bebawy, Mary
    Beckham, Carla
    Zavec, Apolonija Bedina
    Benmoussa, Abderrahim
    Berardi, Anna C.
    Bergese, Paolo
    Bielska, Ewa
    Blenkiron, Cherie
    Bobis-Wozowicz, Sylwia
    Boilard, Eric
    Boireau, Wilfrid
    Bongiovanni, Antonella
    Borras, Francesc E.
    Bosch, Steffi
    Boulanger, Chantal M.
    Breakefield, Xandra
    Breglio, Andrew M.
    Brennan, Meadhbh A.
    Brigstock, David R.
    Brisson, Alain
    Broekman, Marike L. D.
    Bromberg, Jacqueline F.
    Bryl-Gorecka, Paulina
    Buch, Shilpa
    Buck, Amy H.
    Burger, Dylan
    Busatto, Sara
    Buschmann, Dominik
    Bussolati, Benedetta
    Buzas, Edit, I
    Byrd, James Bryan
    Camussi, Giovanni
    [J]. JOURNAL OF EXTRACELLULAR VESICLES, 2018, 7 (01)
  • [65] Endothelial Microparticles in Mild Chronic Obstructive Pulmonary Disease and Emphysema The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
    Thomashow, Michael A.
    Shimbo, Daichi
    Parikh, Megha A.
    Hoffman, Eric A.
    Vogel-Claussen, Jens
    Hueper, Katja
    Fu, Jessie
    Liu, Chia-Ying
    Bluemke, David A.
    Ventetuolo, Corey E.
    Doyle, Margaret F.
    Barr, R. Graham
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 188 (01) : 60 - 68
  • [66] Role of microparticles derived from monocytes, endothelial cells and platelets in the exacerbation of COPD
    Tokes-Fuzesi, Margit
    Ruzsics, Istvan
    Rideg, Orsolya
    Kustan, Peter
    Kovacs, Gabor L.
    Molnar, Tihamer
    [J]. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2018, 13 : 3749 - 3757
  • [67] Classification, Functions, and Clinical Relevance of Extracellular Vesicles
    van der Pol, Edwin
    Boing, Anita N.
    Harrison, Paul
    Sturk, Augueste
    Nieuwland, Rienk
    [J]. PHARMACOLOGICAL REVIEWS, 2012, 64 (03) : 676 - 705
  • [68] Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease
    Wang, Lijing
    Chen, Qiong
    Yu, Qiao
    Xiao, Jian
    Zhao, Hongjun
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 96
  • [69] The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema
    Xia, Haibo
    Wu, Yan
    Zhao, Jing
    Li, Wenqi
    Lu, Lu
    Ma, Huimin
    Cheng, Cheng
    Sun, Jing
    Xiang, Quanyong
    Bian, Tao
    Liu, Qizhan
    [J]. CELL BIOLOGY AND TOXICOLOGY, 2022, 38 (01) : 167 - 183
  • [70] Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
    Xu, Hui
    Ling, Min
    Xue, Junchao
    Dai, Xiangyu
    Sun, Qian
    Chen, Chao
    Liu, Yi
    Zhou, Liang
    Liu, Jianping
    Luo, Fei
    Bian, Qian
    Liu, Qizhan
    [J]. THERANOSTICS, 2018, 8 (19): : 5419 - 5433