Pinning down the polo-box domain

被引：20

作者：

Lee, Kyung S. ^{[1
]}

Idle, Jeffrey R. ^{[2
]}

机构：

[1] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Charles Univ Prague, Inst Pharmacol, Fac Med 1, Prague, Czech Republic

来源：

CHEMISTRY & BIOLOGY | 2008年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.chembiol.2008.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polo-like kinase 1 (Plk1) appears to be an attractive target for anticancer therapy. In this issue of Chemistry & Biology, Reindl et al. (2008) describe the identification of a small molecule called Poloxin that appears to interfere with the function of the polo-box domain (PBD) of Plk1.

引用

页码：415 / 416

页数：2

共 9 条

[1] Polo-like kinases and the orchestration of cell division [J].

Barr, FA ;

Silljé, HHW ;

Nigg, EA .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (06) :429-440

[2] Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice [J].

Chen, Chi ;

Krausz, Kristopher W. ;

Idle, Jeffrey R. ;

Gonzalez, Frank J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (08) :4543-4559

[3] The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex [J].

Cheng, KY ;

Lowe, ED ;

Sinclair, J ;

Nigg, EA ;

Johnson, LN .

EMBO JOURNAL, 2003, 22 (21) :5757-5768

[4] The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain [J].

Elia, AEH ;

Rellos, P ;

Haire, LF ;

Chao, JW ;

Ivins, FJ ;

Hoepker, K ;

Mohammad, D ;

Cantley, LC ;

Smerdon, SJ ;

Yaffe, MB .

CELL, 2003, 115 (01) :83-95

[5]

Lai WG, 1999, J PHARMACOL EXP THER, V291, P292

[6] Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk [J].

Lee, KS ;

Grenfell, TZ ;

Yarm, FR ;

Erikson, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9301-9306

[7] Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol:: Implications for toxic oil syndrome [J].

Martínez-Cabot, A ;

Morató, A ;

Messeguer, A .

CHEMICAL RESEARCH IN TOXICOLOGY, 2005, 18 (11) :1721-1728

[8] Inhibition of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions [J].

Reindl, Wolfgang ;

Yuan, Juping ;

Kraemer, Andrea ;

Strebhardt, Klaus ;

Berg, Thorsten .

CHEMISTRY & BIOLOGY, 2008, 15 (05) :459-466

[9] Opinion - Targeting polo-like kinase 1 for cancer therapy [J].

Strebhardt, K ;

Ullrich, A .

NATURE REVIEWS CANCER, 2006, 6 (04) :321-330

← 1 →