A quantitative comparison of basal ganglia neuronal activities of normal and Parkinson's disease model rats

被引：6

作者：

Ryu, Sang Baek ^{[1
]}

Bae, Eun Kyung ^{[1
]}

Hwang, Yong Sup ^{[2
]}

Lee, Hyun Joo ^{[3
]}

Im, ChangKyun ^{[3
]}

Chang, Jin Woo ^{[2
]}

Shin, Hyung-Cheul ^{[3
]}

Kim, Kyung Hwan ^{[1
]}

机构：

[1] Yonsei Univ, Coll Hlth Sci, Dept Biomed Engn, Wonju 220710, Gangwon Do, South Korea

[2] Yonsei Univ, Coll Med, Dept Neurosurg, Seoul 120752, South Korea

[3] Hallym Univ, Coll Med, Dept Physiol, Chunchon 200702, Gangwon Do, South Korea

来源：

NEUROSCIENCE LETTERS | 2011年 / 505卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Parkinson's disease; Subthalamic nucleus; Substantia nigra pars reticulate; Globus pallidus; Spike train analysis; Neuronal firing pattern; PARS RETICULATA NEURONS; SUBTHALAMIC NUCLEUS; SUBSTANTIA-NIGRA; GLOBUS-PALLIDUS; LESIONS; 6-HYDROXYDOPAMINE; DEGENERATION; STIMULATION; APOMORPHINE; PATTERN;

D O I：

10.1016/j.neulet.2011.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to identify consistent characteristic changes of neuronal activity in basal ganglia (BG) nuclei associated with Parkinson's disease (PD) so that a reliable index of PD can be derived. A simple algorithm for automatic identification of firing patterns was devised as an essential tool to achieve this goal. A detailed quantitative analysis of firing patterns as well as firing rate was performed in three BG nuclei: the subthalamic nucleus (STN), the substantia nigra pars reticulate (SNpr), and the globus pallidus (GP). The results showed that the firing rate of STN neurons was not significantly altered in PD model rats. We also did not find a significant alteration in firing rates in the SNpr and GP between normal and PD model rats. In contrast, consistent changes of firing patterns were observed in all three BG nuclei in that the percentage of neurons with a regular firing pattern decreased whereas those with irregular, mixed, or burst patterns increased. This enables a simple algorithm based on burst detection and the shape of the interspike interval histogram to identify whether the neuronal activity is from normal or PD model rats. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：113 / 118

页数：6

共 25 条

[11]

Kreiss DS, 1997, J NEUROSCI, V17, P6807

[12]

Murer MG, 1997, SYNAPSE, V27, P278, DOI 10.1002/(SICI)1098-2396(199712)27:4<278::AID-SYN2>3.3.CO

[13]

2-S

[14] Time-course of changes in firing rates and firing patterns of subthalamic nucleus neuronal activity after 6-OHDA-induced dopamine depletion in rats [J].

Ni, ZG ;

Bouali-Benazzouz, R ;

Gao, DM ;

Benabid, AL ;

Benazzouz, A .

BRAIN RESEARCH, 2001, 899 (1-2) :142-147

[15]

Ni ZG, 2000, EUR J NEUROSCI, V12, P4338, DOI 10.1111/j.1460-9568.2000.01346.x

[16] A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus [J].

Plenz, D ;

Kital, ST .

NATURE, 1999, 400 (6745) :677-682

[17] The subthalamic nucleus in Parkinson's disease: somatotopic organization and physiological characteristics [J].

Rodriguez-Oroz, MC ;

Rodriguez, M ;

Guridi, J ;

Mewes, K ;

Chockkman, V ;

Vitek, J ;

DeLong, MR ;

Obeso, JA .

BRAIN, 2001, 124 :1777-1790

[18]

ROLFS A, 1997, BRAIN RES, V761, P352

[19] CHANGES IN SUBSTANTIA-NIGRA PARS RETICULATA ACTIVITY FOLLOWING LESIONS OF THE SUBSTANTIA-NIGRA PARS COMPACTA [J].

SANDERSON, P ;

MAVOUNGOU, R ;

ALBEFESSARD, D .

NEUROSCIENCE LETTERS, 1986, 67 (01) :25-30

[20] NEURONS OF THE SUBTHALAMIC NUCLEUS IN PRIMATES DISPLAY GLUTAMATE BUT NOT GABA IMMUNOREACTIVITY [J].

SMITH, Y ;

PARENT, A .

BRAIN RESEARCH, 1988, 453 (1-2) :353-356

← 1 2 3 →