Self-association of verapamil in aqueous electrolyte solution

被引：5
作者：
Taboada, P
Pérez-Rodríguez, M
Attwood, D [1 ]
Varela, LM
Ruso, JM
Mosquera, V
机构：
[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England
[2] Univ Santiago de Compostela, Fac Fis, Dept Fis Mat Condensada, Grp Fis Coloides & Polimeros, E-15706 Santiago De Compostela, Spain
[3] Univ Santiago de Compostela, Fac Fis, Dept Fis Aplicada, E-15706 Santiago De Compostela, Spain
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2001年 / 241卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
verapamil; self-association; critical micelle concentration; nuclear magnetic resonance; dimers;
D O I：
10.1006/jcis.2001.7738
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The self-association of the amphiphilic. drug verapamil hydrochloride in water and in the presence of added electrolyte (0.0-0.009 mol kg(-1) NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques. Aggregation numbers determined by the application of mass action theory to the concentration dependence of H-1 NMR chemical shifts were in agreement with values from static light scattering and indicated very limited association (aggregation numbers between 2 and 4). (C) 2001 Academic Press.
引用
收藏
页码：459 / 464
页数：6
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