Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

被引：203

作者：

Ihrie, Rebecca A. ^{[1
,2
]}

Shah, Jugal K. ^{[1
,2
]}

Harwell, Corey C. ^{[1
,3
]}

Levine, Jacob H. ^{[1
,2
]}

Guinto, Cristina D. ^{[1
,2
]}

Lezameta, Melissa ^{[4
]}

Kriegstein, Arnold R. ^{[1
,3
]}

Alvarez-Buylla, Arturo ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[4] Inst Cavanilles Biodiversitat & Biol Evolut, Valencia 46980, Spain

来源：

NEURON | 2011年 / 71卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SUBVENTRICULAR ZONE; OLFACTORY-BULB; NEURONAL MIGRATION; VASCULAR NICHE; EXPRESSION; BINDING; REVEALS; PROLIFERATION; INTERNEURONS; MAINTENANCE;

D O I：

10.1016/j.neuron.2011.05.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines the type of neuronal progeny NSCs generate, but the mechanism of adult NSC positional specification remains unknown. We show that sonic hedgehog (Shh) signaling, resulting in high gli levels, occurs in the ventral SVZ and is associated with the genesis of specific neuronal progeny. Shh is selectively produced by a small group of ventral forebrain neurons. Ablation of Shh decreases production of ventrally derived neuron types, while ectopic activation of this pathway in dorsal NSCs respecifies their progeny to deep granule interneurons and calbindin-positive periglomerular cells. These results show that Shh is necessary and sufficient for the specification of adult ventral NSCs.

引用

页码：250 / 262

页数：13

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