Secretion without Golgi

被引：100

作者：

Prudovsky, Igor ^{[1
]}

Tarantini, Francesca ^{[2
]}

Landriscina, Matteo ^{[3
]}

Neivandt, David ^{[4
]}

Soldi, Raffaella ^{[1
]}

Kirov, Aleksandr ^{[1
]}

Small, Deena ^{[5
]}

Kathir, Karuppanan Muthusamy ^{[6
]}

Rajalingam, Dakshinamurthy ^{[6
]}

Kumar, Thallapuranam Krishnaswamy Suresh ^{[6
]}

机构：

[1] Maine Med Ctr, Maine Med Ctr Res Inst, Scarborough, ME 04074 USA

[2] Univ Florence, Dept Clin Med & Surg Gerontol & Geriatr, Florence, Italy

[3] Univ Foggia, Dept Med Sci, Clin Oncol Unit, Foggia, Italy

[4] Univ Maine, Dept Chem & Biol Engn, Funct Genom Program, Orono, ME USA

[5] Univ New Hampshire, Dept Biochem & Mol Biol, Durham, NH 03824 USA

[6] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2008年 / 103卷 / 05期

关键词：

non-classical secretion; FGF1; IL1; alpha;

D O I：

10.1002/jcb.21513

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A growing number of proteins devoid of signal peptides have been demonstrated to be released through the non-classical pathways independent of endoplasmic reticulum and Golgi. Among them are two potent proangiogenic cytokines FGF1 and IL1 alpha. Stress-induced transmembrane translocation of these proteins requires the assembly of copper-dependent multiprotein release complexes. It involves the interaction of exported proteins with the acidic phospholipids of the inner leaflet of the cell membrane and membrane destabilization. Not only stress, but also thrombin treatment and inhibition of Notch signaling stimulate the export of FGF1. Non-classical release of FGF1 and IL1 alpha presents a promising target for treatment of cardiovascular, oncologic, and inflammatory disorders.

引用

页码：1327 / 1343

页数：17

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