Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease

被引：60

作者：

Simola, Nicola ^{[1
]}

机构：

[1] Univ Cagliari, Sect Neuropsychopharmacol, Dept Biomed Sci, I-09124 Cagliari, Italy

来源：

CURRENT NEUROPHARMACOLOGY | 2015年 / 13卷 / 02期

关键词：

Analgesic; antidepressant; anxiolytic; drug abuse; drug toxicity; psychostimulant; INDUCED ARTHRITIC RATS; EARLY-LIFE STRESS; ADULT MALE-RATS; DISTRESS VOCALIZATIONS; COCAINE EXPOSURE; PHARMACOLOGICAL MODULATION; SEROTONERGIC MODULATION; NUCLEUS-ACCUMBENS; NMDA ANTAGONISTS; CONDITIONED FEAR;

D O I：

10.2174/1570159X13999150318113800

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivation, and social behavior. Rat USVs are sensitive to the effects of certain classes of psychoactive drugs, suggesting that emission of rat USVs can have relevance not only to neurobiology, but also to neuropharmacology and psychopharmacology. This review summarizes three types of rat USVs, namely 40-kHz USVs emitted by pups, 22-kHz USVs and 50-kHz USVs emitted by young and adult animals, and relevance of these vocalizations to neuropharmacological studies. Attention will be focused on the issues of how rat USVs can be used to evaluate the pharmacological properties of different classes of drugs, and how rat USVs can be combined with other behavioral models used in neuropharmacology. The strengths and limitations of experimental paradigms based on the evaluation of rat USVs will also be discussed.

引用

页码：164 / 179

页数：16

共 146 条

[1] Repeated intravenous amphetamine exposure: Rapid and persistent sensitization of 50-kHz ultrasonic trill calls in rats [J].

Ahrens, Allison M. ;

Ma, Sean T. ;

Maier, Esther Y. ;

Duvauchelle, Christine L. ;

Schallert, Timothy .

BEHAVIOURAL BRAIN RESEARCH, 2009, 197 (01) :205-209

[2]

ALLIN J T, 1971, Developmental Psychobiology, V4, P149, DOI 10.1002/dev.420040206

[3] Levomilnacipran (F2695), a norepinephrine-preferring SNRI: Profile in vitro and in models of depression and anxiety [J].

Auclair, A. L. ;

Martel, J. C. ;

Assie, M. B. ;

Bardin, L. ;

Heusler, P. ;

Cussac, D. ;

Marien, M. ;

Newman-Tancredi, A. ;

O'Connor, J. A. ;

Depoortere, R. .

NEUROPHARMACOLOGY, 2013, 70 :338-347

[4] Neonatal Behavioral Changes in Rats With Gestational Exposure to Lipopolysaccharide: A Prenatal Infection Model for Developmental Neuropsychiatric Disorders [J].

Baharnoori, Moogeh ;

Bhardwaj, Sanjeev K. ;

Srivastava, Lalit K. .

SCHIZOPHRENIA BULLETIN, 2012, 38 (03) :444-456

[5] Cognitive impairment and increased brain neurosteroids in adult rats perinatally exposed to low millimolar blood alcohol concentrations [J].

Barbaccia, Maria Luisa ;

Scaccianoce, Sergio ;

Del Bianco, Paola ;

Campolongo, Patrizia ;

Trezza, Viviana ;

Tattoli, Maria ;

Cuomo, Vincenzo ;

Steardo, Luca .

PSYCHONEUROENDOCRINOLOGY, 2007, 32 (8-10) :931-942

[6] Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats [J].

Bardin, L. ;

Gregoire, S. ;

Aliaga, M. ;

Malfetes, N. ;

Vitton, O. ;

Ladure, P. ;

Newman-Tancredi, A. ;

Depoortere, R. .

NEUROSCIENCE RESEARCH, 2010, 66 (02) :135-140

[7] Ultrasonic Vocalizations as a Measure of Affect in Preclinical Models of Drug Abuse: A Review of Current Findings [J].

Barker, David J. ;

Simmons, Steven J. ;

West, Mark O. .

CURRENT NEUROPHARMACOLOGY, 2015, 13 (02) :193-210

[8] Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration [J].

Barker, David J. ;

Simmons, Steven J. ;

Servilio, Lisa C. ;

Bercovicz, Danielle ;

Ma, Sisi ;

Root, David H. ;

Pawlak, Anthony P. ;

West, Mark O. .

PSYCHOPHARMACOLOGY, 2014, 231 (05) :909-918

[9] Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration [J].

Barker, David J. ;

Root, David H. ;

Ma, Sisi ;

Jha, Shaili ;

Megehee, Laura ;

Pawlak, Anthony P. ;

West, Mark O. .

PSYCHOPHARMACOLOGY, 2010, 211 (04) :435-442

[10] TOLERANCE AND WITHDRAWAL TO CHRONIC MORPHINE TREATMENT IN THE WEEK-OLD RAT PUP [J].

BARR, GA ;

WANG, SN .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 215 (01) :35-42

← 1 2 3 4 5 6 7 8 9 10 →