Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

被引：68

作者：

Jinnou, Hideo ^{[1
,2
]}

Sawada, Masato ^{[1
]}

Kawase, Koya ^{[1
,2
]}

Kaneko, Naoko ^{[1
]}

Herranz-Perez, Vicente ^{[3
,4
]}

Miyamoto, Takuya ^{[1
]}

Kawaue, Takumi ^{[5
]}

Miyata, Takaki ^{[5
]}

Tabata, Yasuhiko ^{[6
]}

Akaike, Toshihiro ^{[7
]}

Manuel Garcia-Verdugo, Jose ^{[3
]}

Ajioka, Itsuki ^{[8
]}

Saitoh, Shinji ^{[2
]}

Sawamoto, Kazunobu ^{[1
,9
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Dev & Regenerat Biol, Nagoya, Aichi 4678601, Japan

[2] Nagoya City Univ, Grad Sch Med Sci, Dept Pediat & Neonatol, Nagoya, Aichi 4678601, Japan

[3] Univ Valencia, CIBERNED, Inst Cavanilles, Lab Neurobiol Comparada, Valencia 46980, Spain

[4] Univ Jaume 1, Fac Hlth Sci, Predept Unit Med, Castellon de La Plana 12071, Spain

[5] Nagoya Univ, Grad Sch Med, Dept Anat & Cell Biol, Nagoya, Aichi 4668550, Japan

[6] Kyoto Univ, Inst Frontier Life & Med Sci, Dept Regenerat Sci & Engn, Lab Biomat, Kyoto 6068507, Japan

[7] Fdn Adv Int Sci, Biomat Ctr Regenerat Med Engn, Tsukuba, Ibaraki 3050821, Japan

[8] Tokyo Med & Dent Univ, Ctr Brain Integrat Res, Tokyo 1138510, Japan

[9] Natl Inst Physiol Sci, Div Neural Dev & Regenerat, Okazaki, Aichi 4448585, Japan

来源：

CELL STEM CELL | 2018年 / 22卷 / 01期

关键词：

NEURAL STEM-CELLS; CEREBRAL-CORTEX; ADULT BRAIN; N-CADHERIN; NEUROGENESIS; ADHESION; INTERNEURONS; TRAFFICKING; MECHANISMS; ASTROCYTES;

D O I：

10.1016/j.stem.2017.11.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during postnatal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries.

引用

页码：128 / +

页数：19

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