Schulzeines A-C, new α-glucosidase inhibitors from the marine sponge Penares schulzei

被引：94
作者：
Takada, K
Uehara, T
Nakao, Y
Matsunaga, S
van Soest, RWM
Fusetani, N [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan
[2] Univ Amsterdam, Zool Museum, Inst Biodivers & Ecosyst Dynam, NL-1090 GT Amsterdam, Netherlands
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 01期
关键词：
D O I：
10.1021/ja037368r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C-28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit alpha-glucosidase with IC50 values of 48-170 nM.
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页码：187 / 193
页数：7
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