A convenient synthesis of pyrrolo[3,4-c]quinolines

被引：15
|
作者：
Virányi, A
Nyerges, M
Blaskó, G
Töke, L
机构：
[1] Tech Univ Budapest, Dept Organ Chem Technol, Hungarian Acad Sci, Res Grp, H-1521 Budapest, Hungary
[2] Egis Pharmaceut, H-1475 Budapest, Hungary
来源：
SYNTHESIS-STUTTGART | 2003年 / 17期
关键词：
amino acids; cyclizations; cycloaddition; lactams; quinolines;
D O I：
10.1055/s-2003-42425
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new route to the pyrrolo[3,4-c]quinoline ring system has been developed. The synthesis proceeds stereoselectively in three steps, using 1,3-dipolar cycloaddition of azomethine ylides as a key step. First, a series of 4-arylpyrrolidine-3-carboxylic acids have been prepared from the appropriate cinnamic esters and a non-stabilized azomethine ylide. The reduction of a nitro group on the aromatic ring was followed by acid-catalyzed intramolecular lactam formation.
引用
收藏
页码：2655 / 2660
页数：6
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