GATA transcription factors in development and disease

被引：170
作者：
Tremblay, Mathieu
Sanchez-Ferras, Oraly
Bouchard, Maxime [1 ]
机构：
[1] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada
来源：
DEVELOPMENT | 2018年 / 145卷 / 20期
基金：
加拿大健康研究院;
关键词：
GATA factors; Gene redundancy; Genetics; Lineage specification; Mouse development; Transcription; Human diseases; MAST-CELL DIFFERENTIATION; HUMAN HEMATOPOIETIC STEM; OF-FUNCTION MUTATION; LOCUS-CONTROL REGION; ZINC-FINGER PROTEIN; DNA-BINDING; GENE-EXPRESSION; REGULATES DIFFERENTIATION; RECEPTOR EXPRESSION; HEART MORPHOGENESIS;
D O I：
10.1242/dev.164384
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis. GATA proteins are essential for the development of tissues derived from all three germ layers, including the skin, brain, gonads, liver, hematopoietic, cardiovascular and urogenital systems. The crucial activity of GATA factors is underscored by the fact that inactivating mutations in most GATA members lead to embryonic lethality in mouse models and are often associated with developmental diseases in humans. In this Primer, we discuss the unique and redundant functions of GATA proteins in tissue morphogenesis, with an emphasis on their regulation of lineage specification and early organogenesis.
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页数：20
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共 300 条
[31]   Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice [J].
Chia, Ian ;
Grote, David ;
Marcotte, Michael ;
Batourina, Ekaterina ;
Mendelsohn, Cathy ;
Bouchard, Maxime .
DEVELOPMENT, 2011, 138 (10) :2089-2097
[32]   Expression of GATA-3 in epidermis and hair follicle: Relationship to p63 [J].
Chikh, Anissa ;
Sayan, Emre ;
Thibaut, Sebastien ;
Lena, Anna Maria ;
DiGiorgi, Sabrina ;
Bernard, Bruno A. ;
Melino, Gerry ;
Candi, Eleonora .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (01) :1-6
[33]   Combinatorial regulation of tissue specification by GATA and FOG factors [J].
Chlon, Timothy M. ;
Crispino, John D. .
DEVELOPMENT, 2012, 139 (21) :3905-3916
[34]   Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy [J].
Chun, TH ;
Itoh, H ;
Subramanian, L ;
Iñiguez-Lluhí, JA ;
Nakao, K .
CIRCULATION RESEARCH, 2003, 92 (11) :1201-1208
[35]   Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4 [J].
Cirillo, LA ;
Lin, FR ;
Cuesta, I ;
Friedman, D ;
Jarnik, M ;
Zaret, KS .
MOLECULAR CELL, 2002, 9 (02) :279-289
[36]   Retinoid X receptor a represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2 [J].
Clabby, ML ;
Robinson, TA ;
Quigley, HF ;
Wilson, DB ;
Kelly, DP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :5760-5767
[37]   The Functional Diversity of Essential Genes Required for Mammalian Cardiac Development [J].
Clowes, Christopher ;
Boylan, Michael G. S. ;
Ridge, Liam A. ;
Barnes, Emma ;
Wright, Jayne A. ;
Hentges, Kathryn E. .
GENESIS, 2014, 52 (08) :713-737
[38]   Modification of the erythroid transcription factor GATA-1 by SUMO-1 [J].
Collavin, L ;
Gostissa, M ;
Avolio, F ;
Secco, P ;
Ronchi, A ;
Santoro, C ;
Del Sal, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (24) :8870-8875
[39]   GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice [J].
Convissar, Scott M. ;
Bennett, Jill ;
Baumgarten, Sarah C. ;
Lydon, John P. ;
DeMayo, Francesco J. ;
Stocco, Carlos .
BIOLOGY OF REPRODUCTION, 2015, 93 (06)
[40]   Gata2 specifies serotonergic neurons downstream of sonic hedgehog [J].
Craven, SE ;
Lim, KC ;
Ye, WL ;
Engel, JD ;
de Sauvage, F ;
Rosenthal, A .
DEVELOPMENT, 2004, 131 (05) :1165-1173
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