NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma

被引：12
作者：
Liu, Rongqiang [1 ,2 ,3 ]
Li, Rongqi [4 ]
Yu, Haoyuan [1 ,2 ]
Liu, Jianrong [5 ]
Zheng, Shiyang [6 ]
Li, Yang [1 ,2 ]
Ye, Linsen [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hepat Surg, Guangzhou, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 3, Liver Transplantat Ctr, Guangzhou, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou, Peoples R China
[4] Foshan Hosp Tradit Chinese Med, Dept Hepatobiliary Surg, Foshan, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 3, Surg & Transplant Intens Care Unit, Guangzhou, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 3, Dept Breast Surg, Guangzhou, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2021年 / 8卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
NTF3; hepatocellular carcinoma; prognosis; immune infiltrates; TGCA; REGULATORY T-CELLS; GENE-EXPRESSION; CORE BIOPSY; CANCER; THERAPY; TARGET; NEEDLE; ATR;
D O I：
10.3389/fmed.2021.795849
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The potential role of Neurotrophic factor-3(NTF3) in liver cancer is unknown. Therefore, we aimed to explore the clinical value of NTF3 in hepatocellular carcinoma (HCC).Methods: We used a variety of databases to analyze the expression, relationship with prognosis and immune significance of NTF3 in liver cancer through bioinformatics.Results: NTF3 was low expressed in HCC and was an independent prognostic factor in patients with HCC. CIBERSORT analysis indicated that NTF3 expression was positively correlated with CD4+ cells, mast cells, NK cells, macrophages and B cells in the tumor microenvironment. Furthermore, we found that NTF3 expression was negatively correlated with the immune checkpoints PD-L1, TIGIT and TIM-3. Functional network analysis revealed that NTF3 regulates HCC progression through a variety of cancer-related kinases, transcription factors and signaling pathways.Conclusions: We demonstrate that NTF3 correlates with prognosis and immune infiltration in HCC.
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页数：13
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