Diverse Functions of Pulmonary Collectins in Host Defense of the Lung

被引:43
作者
Ariki, Shigeru [1 ]
Nishitani, Chiaki [1 ]
Kuroki, Yoshio [1 ]
机构
[1] Sapporo Med Univ, Dept Biochem, Sch Med, Chuo Ku, Sapporo, Hokkaido 0608556, Japan
来源
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年
关键词
SURFACTANT-PROTEIN-A; ALVEOLAR MACROPHAGE PHAGOCYTOSIS; CARBOHYDRATE-RECOGNITION DOMAIN; RESPIRATORY SYNCYTIAL VIRUS; PSEUDOMONAS-AERUGINOSA; DEFICIENT MICE; IN-VIVO; D BINDS; BACTERIAL LIPOPOLYSACCHARIDES; STAPHYLOCOCCUS-AUREUS;
D O I
10.1155/2012/532071
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Pulmonary surfactant is a mixture of lipids and proteins that covers alveolar surfaces and keeps alveoli from collapsing. Four specific proteins have been identified in surfactant. Among them, two C-type lectins, surfactant proteins A and D (SP-A and SP-D), are known to be implicated in host defense and regulation of inflammatory responses of the lung. These host defense lectins are structurally characterized by N-terminal collagen-like domains and lectin domains and are called pulmonary collectins. They prevent dissemination of infectious microbes by their biological activities including agglutination and growth inhibition. They also promote clearance of microbes by enhancing phagocytosis in macrophages. In addition, they interact with the other pattern-recognition molecules, including Toll-like receptors (TLRs) and TLR-associated molecules, CD14 and MD-2, and regulate inflammatory responses. Furthermore, recent studies have demonstrated that these collectins modulate functions of neutrophil-derived innate immune molecules by interacting with them. These findings indicate that pulmonary collectins play critical roles in host defense of the lung.
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页数:7
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