Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

被引：131

作者：

Dong, Suzhen ^{[1
,2
]}

Zeng, Qingwen ^{[1
]}

Mitchell, E. Siobhan ^{[3
]}

Xiu, Jin ^{[4
]}

Duan, Yale ^{[1
]}

Li, Chunxia ^{[1
]}

Tiwari, Jyoti K. ^{[5
]}

Hu, Yinghe ^{[1
,2
]}

Cao, Xiaohua ^{[1
]}

Zhao, Zheng ^{[1
]}

机构：

[1] E China Normal Univ, Key Lab Brain Funct Genom, Minist Educ, Key Lab Brain Funct Genom, Shanghai 200062, Peoples R China

[2] E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China

[3] Unilever R&D, Vlaardingen, Netherlands

[4] Unilever R&D, Shanghai, Peoples R China

[5] Unilever R&D, Bangalore, Karnataka, India

来源：

PLOS ONE | 2012年 / 7卷 / 02期

关键词：

ADULT HIPPOCAMPAL NEUROGENESIS; ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; ADENYLYL-CYCLASE; OXIDATIVE STRESS; SPATIAL MEMORY; MESSENGER-RNA; EXPRESSION; NEURONS; IMPAIRMENT;

D O I：

10.1371/journal.pone.0031211

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Curcumin has been demonstrated to have many neuroprotective properties, including improvement of cognition in humans and neurogenesis in animals, yet the mechanism of such effects remains unclear. Methodology: We assessed behavioural performance and hippocampal cell proliferation in aged rats after 6- and 12-week curcumin-fortified diets. Curcumin enhanced non-spatial and spatial memory, as well as dentate gyrate cell proliferation as compared to control diet rats. We also investigated underlying mechanistic pathways that might link curcumin treatment to increased cognition and neurogenesis via exon array analysis of cortical and hippocampal mRNA transcription. The results revealed a transcriptional network interaction of genes involved in neurotransmission, neuronal development, signal transduction, and metabolism in response to the curcumin treatment. Conclusions: The results suggest a neurogenesis- and cognition-enhancing potential of prolonged curcumin treatment in aged rats, which may be due to its diverse effects on genes related to growth and plasticity.

引用

页数：12

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