Characteristics of pediatric recurrent erythema multiforme

被引:17
作者
Heinze, Adam [1 ]
Tollefson, Megha [2 ,3 ]
Holland, Kristen E. [4 ,5 ]
Chiu, Yvonne E. [4 ,5 ]
机构
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Mayo Clin, Dept Dermatol, Sect Pediat Dermatol, Rochester, MN USA
[3] Mayo Clin, Dept Pediat, Sect Pediat Dermatol, Rochester, MN USA
[4] Med Coll Wisconsin, Dept Dermatol, Sect Pediat Dermatol, Milwaukee, WI 53226 USA
[5] Med Coll Wisconsin, Dept Pediat, Sect Pediat Dermatol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA
关键词
children; chronic erythema multiforme; erythema multiforme; recurrent erythema multiforme; HERPES-SIMPLEX-VIRUS; INFECTION; THERAPY; DNA;
D O I
10.1111/pde.13357
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BackgroundErythema multiforme (EM) is an acute condition characterized by distinctive target lesions of the skin often accompanied by mucosal ulcers. A subset of individuals experience frequent episodes of recurrent EM, which is rare and poorly understood, especially in children. ObjectiveTo characterize clinical features, laboratory findings, and treatment responses of pediatric recurrent EM. MethodsA retrospective chart review was conducted at the Children's Hospital of Wisconsin in Milwaukee, Wisconsin (2000-2015) and the Mayo Clinic in Rochester, Minnesota (1990-2015). Inclusion criterion was a diagnosis before age 18 years with recurrent EM, defined as a symmetrically distributed, fixed eruption, including target lesions, with or without mucous membrane involvement, occurring on at least three occasions. A literature review was conducted to include individuals who met the inclusion criterion. ResultsTwenty-six patients were included, of whom 16 (62%) were male. The median age of onset was 9.1years (range 0-15.7years). Nine patients (35%) required hospitalization. Herpes simplex virus testing was positive in 9 of 17 (65%) patients. Remission was achieved in 5 of 16 (31%) patients while taking suppressive antivirals. Eight patients received continuous anti-inflammatory treatment, two (25%) of whom experienced remission. ConclusionThis study of pediatric recurrent EM found a greater male predominance, more hospitalizations, fewer cases caused by herpes simplex virus, and alower response to immunosuppression in children than in the general population.
引用
收藏
页码:97 / 103
页数:7
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