Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine, in rat models of inflammatory pain

被引：0
|
作者：
Bowes, M
Panesar, M
Gentry, C
Urban, L
Gasparini, F
Kuhn, R
Walker, K
机构：
[1] Novartis Pharma AG, Basel, Switzerland
[2] Novartis Inst Med Sci, London WC1E 6BN, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1999年 / 126卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
250P
引用
收藏
页码：U130 / U130
页数：1
相关论文
共 50 条
  • [41] The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats
    Sotgiu, ML
    Bellomi, P
    Biella, GEM
    NEUROSCIENCE LETTERS, 2003, 342 (1-2) : 85 - 88
  • [42] Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2(phenylethynyl)-pyridine (MPEP) in the thalamus
    Salt, TE
    Binns, KE
    Turner, JP
    Gasparini, F
    Kuhn, R
    BRITISH JOURNAL OF PHARMACOLOGY, 1999, 127 (05) : 1057 - 1059
  • [43] Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents:: Detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]
    Satow, Akio
    Maehara, Shunsuke
    Ise, Satoko
    Hikichi, Hirohiko
    Fukushima, Miyuki
    Suzuki, Gentaroh
    Kimura, Toshifumi
    Tanaka, Takeshi
    Ito, Satoru
    Kawamoto, Hiroshi
    Ohta, Hisashi
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 326 (02): : 577 - 586
  • [44] Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes)
    Wang, SJ
    Sihra, TS
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 309 (03): : 951 - 958
  • [45] 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
    Cosford, NDP
    Tehrani, L
    Roppe, J
    Schweiger, E
    Smith, ND
    Anderson, J
    Bristow, L
    Brodkin, J
    Jiang, XH
    McDonald, I
    Rao, S
    Washburn, M
    Varney, MA
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (02) : 204 - 206
  • [46] The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1α-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors
    Pagano, A
    Rüegg, D
    Litschig, S
    Stoehr, N
    Stierlin, C
    Heinrich, M
    Floersheim, P
    Prezèau, L
    Carroll, F
    Pin, JP
    Cambria, A
    Vranesic, I
    Flor, PJ
    Gasparini, F
    Kuhn, R
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (43) : 33750 - 33758
  • [47] Effects of the novel 5-HT6 receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating
    Schreiber, Rudy
    Vivian, Jef
    Hedley, Linda
    Szczepanski, Krystine
    Secchi, Rob L.
    Zuzow, Marcus
    van Laarhoven, Susanne
    Moreau, Jean-Luc
    Martin, James R.
    Sik, Ayhan
    Blokland, Arjan
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 (04) : 277 - 288
  • [48] Structure-Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists
    Kulkarni, Santosh S.
    Zou, Mu-Fa
    Cao, Jianjing
    Deschamps, Jeffrey R.
    Rodriguez, Alice L.
    Conn, P. Jeffrey
    Newman, Amy Hauck
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (11) : 3563 - 3575
  • [49] A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models
    Kinney, GG
    O'Brien, JA
    Lemaire, W
    Burno, M
    Bickel, DJ
    Clements, MK
    Chen, TB
    Wisnoski, DD
    Lindsley, CW
    Tiller, PR
    Smith, S
    Jacobson, MA
    Sur, C
    Duggan, ME
    Pettibone, DJ
    Conn, PJ
    Williams, DL
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01): : 199 - 206
  • [50] 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP): A potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
    Varney, M
    Anderson, J
    Bradbury, M
    Bristow, L
    Brodkin, J
    Giracello, D
    Jachec, C
    Holtz, G
    Prasit, P
    Rao, S
    Chapman, D
    Cosford, NDP
    NEUROPHARMACOLOGY, 2002, 43 (02) : 311 - 311
12345