Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine, in rat models of inflammatory pain

被引：0
|
作者：
Bowes, M
Panesar, M
Gentry, C
Urban, L
Gasparini, F
Kuhn, R
Walker, K
机构：
[1] Novartis Pharma AG, Basel, Switzerland
[2] Novartis Inst Med Sci, London WC1E 6BN, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1999年 / 126卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
250P
引用
收藏
页码：U130 / U130
页数：1
相关论文
共 50 条
  • [31] The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats
    Una C. Campbell
    Kush Lalwani
    Lisa Hernandez
    Gene G. Kinney
    P. Jeffrey Conn
    Linda J. Bristow
    Psychopharmacology, 2004, 175 : 310 - 318
  • [32] The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats
    Campbell, UC
    Lalwani, K
    Hernandez, L
    Kinney, GG
    Conn, PJ
    Bristow, LJ
    PSYCHOPHARMACOLOGY, 2004, 175 (03) : 310 - 318
  • [33] Anticonvulsant action in mice of a systemically-active, selective mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine, (MPEP).
    Chapman, AG
    Nanan, K
    Meldrum, BS
    Williams, M
    EPILEPSIA, 1999, 40 : 136 - 136
  • [34] The mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) differentially affects intravenous self-administration (IVSA) of ketamine and heroin in the rat
    van der Kam, E. L.
    De Vry, J.
    Tzschentke, T. M.
    BEHAVIOURAL PHARMACOLOGY, 2007, 18 : S22 - S22
  • [35] The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine
    Tronci, Valeria
    Vronskaya, Svetlana
    Montgomery, Nicholas
    Mura, Daniela
    Balfour, David J. K.
    PSYCHOPHARMACOLOGY, 2010, 211 (01) : 33 - 42
  • [36] The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine
    Valeria Tronci
    Svetlana Vronskaya
    Nicholas Montgomery
    Daniela Mura
    David J. K. Balfour
    Psychopharmacology, 2010, 211 : 33 - 42
  • [37] Members of a novel benzamide structural class act as positive alloseric modulators of metbotropic glutamate receptor subtype 5 by binding to a site other that of 2-methyl-6-(phenylethynyl)-pyridine and its analogs
    Hammond, A. S.
    Rodriguez, A. L.
    Lindsley, C. W.
    Conn, P. J.
    NEUROPHARMACOLOGY, 2008, 55 (04) : 601 - 601
  • [38] The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain
    Tronci, Valeria
    Balfour, David J. K.
    BEHAVIOURAL BRAIN RESEARCH, 2011, 219 (02) : 354 - 357
  • [39] The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats
    Rutten, Kris
    van der Kam, Elizabeth L.
    De Vry, Jean
    Bruckmann, Walter
    Tzschentke, Thomas M.
    ADDICTION BIOLOGY, 2011, 16 (01) : 108 - 115
  • [40] Effects of 2-methyl-6-(phenylethyl)-pyridine (MPEP) - a selective mGluR5 receptor antagonist - on the behaviour of rats in an open field test in a situation of predicted inevitable stress
    Nawrocka, Malgorzata
    Kowalczyk, Marek
    MEDYCYNA WETERYNARYJNA, 2012, 68 (06) : 376 - 379
12345