Combinatorial and rational approaches to polymer synthesis for medicine

被引：36

作者：

Goldberg, Michael ^{[1
,2
]}

Mahon, Kerry ^{[3
]}

Anderson, Daniel ^{[3
]}

机构：

[1] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

[3] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 09期

关键词：

combinatorial; polymer; synthesis; stem cells; nucleic acid delivery; rational design; drug delivery;

D O I：

10.1016/j.addr.2008.02.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High-throughput, combinatorial methods have revolutionized small molecule synthesis and drug discovery. By combining automation, miniaturization, and parallel synthesis techniques, large collections of new compounds have been synthesized and screened. It is becoming increasingly clear that these same approaches can also assist the discovery and development of novel biomaterials for medicine. This review examines combinatorial and rational polymer synthesis for medical applications, including stem cell engineering and nucleic acid drug delivery. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：971 / 978

页数：8

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