Increased expression of proinflammatory cytokines and iNOS in the neocortical microvasculature of patients with temporal lobe epilepsy

被引:19
作者
Castaneda-Cabral, Jose Luis [1 ,2 ]
Urena-Guerrero, Monica E. [2 ]
Beas-Zarate, Carlos [2 ]
Colunga-Duran, Adacrid [1 ]
Nunez-Lumbreras, Maria de los Angeles [1 ]
Orozco-Suarez, Sandra [3 ]
Alonso-Vanegas, Mario [4 ,5 ]
Guevara-Guzman, Rosalinda [6 ]
Deli, Maria A. [7 ]
Rocha, Luisa [1 ]
机构
[1] Inst Politecn Nacl Cinvestav, Dept Farmacobiol, Ctr Invest & Estudios Avanzados, Sede Sur, Calz Tenorios 235, Mexico City 14330, DF, Mexico
[2] Univ Guadalajara, Dept Biol Celular & Mol, Ctr Univ Ciencias Biol & Agr CUCBA, Zapopan, Jalisco, Mexico
[3] Hosp Especialidades Ctr Med La Raza, Unidad Invest Med Enfermedades Neurol, Ctr Med Nacl Siglo XXI, IMSS, Mexico City, DF, Mexico
[4] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Serv Neurocirugia, Mexico City, DF, Mexico
[5] Hosp HMG Coyoacan, Ctr Int Cirugia Epilepsia, Mexico City, DF, Mexico
[6] Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Mexico City, DF, Mexico
[7] Hungarian Acad Sci, Biol Res Ctr, Inst Biophys, Szeged, Hungary
关键词
BLOOD-BRAIN-BARRIER; INFLAMMATORY MEDIATORS; SEX-DIFFERENCES; SEIZURES; TARGETS;
D O I
10.1007/s12026-020-09139-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:169 / 176
页数:8
相关论文
共 35 条
[1]   Overview and introduction: The blood-brain barrier in health and disease [J].
Abbott, N. Joan ;
Friedman, Alon .
EPILEPSIA, 2012, 53 :1-6
[2]   Sex differences in demographic and clinical characteristics of psychogenic nonepileptic seizures: A retrospective multicenter international study [J].
Asadi-Pooya, Ali A. ;
Myers, Lorna ;
Valente, Kette ;
Restrepo, Anilu Daza ;
D'Alessio, Luciana ;
Sawchuk, Tyson ;
Homayoun, Maryam ;
Bahrami, Zahra ;
Alessi, Ruda ;
Paytan, Angelica Aroni ;
Kochen, Silvia ;
Buchhalter, Jeffrey ;
Taha, Firas ;
Lazar, Lorraine M. ;
Pick, Susannah ;
Nicholson, Imothy .
EPILEPSY & BEHAVIOR, 2019, 97 :154-157
[3]   Vascular Integrity and Signaling Determining Brain Development, Network Excitability, and Epileptogenesis [J].
Baruah, Jugajyoti ;
Vasudevan, Anju ;
Koehling, Ruediger .
FRONTIERS IN PHYSIOLOGY, 2020, 10
[4]   Glucocorticoids, Sex Hormones, and immunity [J].
Bereshchenko, Oxana ;
Bruscoli, Stefano ;
Riccardi, Carlo .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[5]   Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy [J].
Dadas, Aaron ;
Janigro, Damir .
NEUROBIOLOGY OF DISEASE, 2019, 123 :20-26
[6]   Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients [J].
Fabian Mercado-Gomez, Octavio ;
Cordova-Davalos, Laura ;
Garcia-Betanzo, Delfina ;
Rocha, Luisa ;
Arturo Alonso-Vanegas, Mario ;
Cienfuegos, Jesus ;
Guevara-Guzman, Rosalinda .
EPILEPSY RESEARCH, 2018, 148 :37-43
[7]   Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy [J].
Gales, Jordan M. ;
Prayson, Richard A. .
ANNALS OF DIAGNOSTIC PATHOLOGY, 2017, 30 :12-16
[8]  
Gong Guo-Hua, 2018, Oncotarget, V9, P8542, DOI 10.18632/oncotarget.24012
[9]   Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines [J].
Kan, Anne A. ;
de Jager, Wilco ;
de Wit, Marina ;
Heijnen, Cobi ;
van Zuiden, Mirjam ;
Ferrier, Cyrill ;
van Rijen, Peter ;
Gosselaar, Peter ;
Hessel, Ellen ;
van Nieuwenhuizen, Onno ;
de Graan, Pierre N. E. .
JOURNAL OF NEUROINFLAMMATION, 2012, 9
[10]   Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature [J].
Klement, Wendy ;
Garbelli, Rita ;
Zub, Emma ;
Rossini, Laura ;
Tassi, Laura ;
Girard, Benoit ;
Blaquiere, Marine ;
Bertaso, Federica ;
Perroy, Julie ;
de Bock, Frederic ;
Marchi, Nicola .
NEUROBIOLOGY OF DISEASE, 2018, 113 :70-81