Ferroptosis: A New Strategy for Cancer Therapy

被引：20

作者：

Chen, Yu ^{[1
]}

Fan, Zhihua ^{[2
]}

Hu, Shen ^{[3
]}

Lu, Chengchao ^{[1
]}

Xiang, Yi ^{[1
]}

Liao, Shuzhi ^{[1
]}

机构：

[1] Guangdong Women & Children Hosp, Dept Pediat Surg, Guangzhou, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Dept Obstet, Sch Med, Hangzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

ferroptosis; cancer; iron; programmed cell death; clinical application; ERASTIN-INDUCED FERROPTOSIS; CELL-DEATH; TRANSSULFURATION PATHWAY; LIPID-PEROXIDATION; IRON; TEMOZOLOMIDE; INHIBITION; METABOLISM; ACTIVATION; FORM;

D O I：

10.3389/fonc.2022.830561

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrence and development of a variety of cancers, especially in the drug resistance. This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application.

引用

页数：8

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