COVID-19: organoids go viral

被引:49
作者
Clevers, Hans [1 ,2 ]
机构
[1] Royal Netherlands Acad Arts & Sci KNAW, Hubrecht Inst, Oncode Inst, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Utrecht, Netherlands
关键词
D O I
10.1038/s41580-020-0258-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The coronavirus disease-19 (COVID-19) pandemic underscores the threat posed by newly emerging viruses. Understanding the biology of novel viruses rests in large part on in vitro models that allow viral replication. Human and animal organoids are now proving their value as an experimental virology platform. Hans Clevers discusses the value of organoids as an experimental platform for understanding the biology of novel viruses.
引用
收藏
页码:355 / 356
页数:2
相关论文
共 10 条
  • [1] Identification of New Respiratory Viruses in the New Millennium
    Berry, Michael
    Gamieldien, Junaid
    Fielding, Burtram C.
    [J]. VIRUSES-BASEL, 2015, 7 (03): : 996 - 1019
  • [2] Replication of human noroviruses in stem cell-derived human enteroids
    Ettayebi, Khalil
    Crawford, Sue E.
    Murakami, Kosuke
    Broughman, James R.
    Karandikar, Umesh
    Tenge, Victoria R.
    Neill, Frederick H.
    Blutt, Sarah E.
    Zeng, Xi-Lei
    Qu, Lin
    Kou, Baijun
    Opekun, Antone R.
    Burrin, Douglas
    Graham, David Y.
    Ramani, Sasirekha
    Atmar, Robert L.
    Estes, Mary K.
    [J]. SCIENCE, 2016, 353 (6306) : 1387 - 1393
  • [3] Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures
    Hui, Kenrie P. Y.
    Ching, Rachel H. H.
    Chan, Stan K. H.
    Nicholls, John M.
    Sachs, Norman
    Clevers, Hans
    Peiris, J. S. Malik
    Chan, Michael C. W.
    [J]. LANCET RESPIRATORY MEDICINE, 2018, 6 (11) : 846 - 854
  • [4] SARS-CoV-2 productively infects human gut enterocytes
    Lamers, Mart M.
    Beumer, Joep
    van der Vaart, Jelte
    Knoops, Kevin
    Puschhof, Jens
    Breugem, Tim I.
    Ravelli, Raimond B. G.
    van Schayck, J. Paul
    Mykytyn, Anna Z.
    Duimel, Hans Q.
    van Donselaar, Elly
    Riesebosch, Samra
    Kuijpers, Helma J. H.
    Schipper, Debby
    van de Wetering, Willine J.
    de Graafl, Miranda
    Koopmans, Marion
    Cuppen, Edwin
    Peters, Peter J.
    Haagmans, Bart L.
    Clevers, Hans
    [J]. SCIENCE, 2020, 369 (6499) : 50 - +
  • [5] Organogenesis in a dish: Modeling development and disease using organoid technologies
    Lancaster, Madeline A.
    Knoblich, Juergen A.
    [J]. SCIENCE, 2014, 345 (6194)
  • [6] Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
    Monteil, Vanessa
    Kwon, Hyesoo
    Prado, Patricia
    Hagelkruys, Astrid
    Wimmer, Reiner A.
    Stahl, Martin
    Leopoldi, Alexandra
    Garreta, Elena
    del Pozo, Carmen Hurtado
    Prosper, Felipe
    Romero, Juan Pablo
    Wirnsberger, Gerald
    Zhang, Haibo
    Slutsky, Arthur S.
    Conder, Ryan
    Montserrat, Nuria
    Mirazimi, Ali
    Penninger, Josef M.
    [J]. CELL, 2020, 181 (04) : 905 - +
  • [7] Consequences of congenital Zika virus infection
    Platt, Derek J.
    Miner, Jonathan J.
    [J]. CURRENT OPINION IN VIROLOGY, 2017, 27 : 1 - 7
  • [8] TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
    Zang, Ruochen
    Castro, Maria Florencia Gomez
    McCune, Broc T.
    Zeng, Qiru
    Rothlauf, Paul W.
    Sonnek, Naomi M.
    Liu, Zhuoming
    Brulois, Kevin F.
    Wang, Xin
    Greenberg, Harry B.
    Diamond, Michael S.
    Ciorba, Matthew A.
    Whelan, Sean P. J.
    Ding, Siyuan
    [J]. SCIENCE IMMUNOLOGY, 2020, 5 (47)
  • [9] Infection of bat and human intestinal organoids by SARS-CoV-2
    Zhou Jie
    Li Cun
    Liu Xiaojuan
    Chiu Man Chun
    Zhao Xiaoyu
    Wang Dong
    Wei Yuxuan
    Lee, Andrew
    Zhang, Anna Jinxia
    Chu Hin
    Cai Jian-Piao
    Yip, Cyril Chik-Yan
    Chan, Ivy Hau-Yee
    Wong, Kenneth Kak-Yuen
    Tsang, Owen Tak-Yin
    Chan Kwok-Hung
    Chan, Jasper Fuk-Woo
    To, Kelvin Kai-Wang
    Chen Honglin
    Yuen, Kwok Yung
    [J]. NATURE MEDICINE, 2020, 26 (07) : 1077 - +
  • [10] Differentiated human airway organoids to assess infectivity of emerging influenza virus
    Zhou, Jie
    Li, Cun
    Sachs, Norman
    Chiu, Man Chun
    Wong, Bosco Ho-Yin
    Chu, Hin
    Poon, Vincent Kwok-Man
    Wang, Dong
    Zhao, Xiaoyu
    Wen, Lei
    Song, Wenjun
    Yuan, Shuofeng
    Wong, Kenneth Kak-Yuen
    Chan, Jasper Fuk-Woo
    To, Kelvin Kai-Wang
    Chen, Honglin
    Clevers, Hans
    Yuen, Kwok-Yung
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (26) : 6822 - 6827