Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing

被引：89
作者：
Chen, Yuting [1 ,2 ]
Cai, Jinhong [1 ,3 ]
Liu, Dachang [1 ,2 ]
Liu, Shuhan [1 ,3 ]
Lei, Doudou [1 ,3 ]
Zheng, Li [1 ,3 ,4 ]
Wei, Qingjun [1 ,2 ,3 ]
Gao, Ming [1 ,3 ]
机构：
[1] Guangxi Med Univ, Guangxi Engn Ctr Biomed Mat Tissue & Organ Regene, Affiliated Hosp 1, 22 Shuangyong Rd, Nanning 530021, Peoples R China
[2] Guangxi Med Univ, Dept Orthopaed Trauma & Hand Surg, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning 530021, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 1, Guangxi Collaborat Innovat Ctr Regenerat Med & Me, 22 Shuangyong Rd, Nanning 530021, Peoples R China
[4] Guangxi Med Univ, Affiliated Hosp 1, Guangxi Key Lab Regenerat Med, 22 Shuangyong Rd, Nanning 530021, Peoples R China
来源：
REGENERATIVE BIOMATERIALS | 2022年 / 9卷
基金：
中国国家自然科学基金;
关键词：
zinc ions; metal organic framework; antibacterial; anti-inflammatory; skin wound healing; ANTIOXIDANT; CYTOTOXICITY;
D O I：
10.1093/rb/rbac019
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The synergistic effect of antibacterial and anti-inflammatory is needed to overcome the problem of wound healing difficulties. Based on the favorable antibacterial and anti-inflammatory effect of zinc ions (Zn2+) and the physicochemical properties of metal organic frameworks (MOFs), we prepared nanosized zinc-based MOF: Zn-BTC with the ability to slowly release Zn2+. In cellular levels, Zn-BTC possessed lower toxicity to fibroblasts and enhanced capacity of cell proliferation and migration. It also had good bactericidal effect on multiple drug-resistant bacteria by reducing 41.4% MRSA and 47.2% Escherichia coli. In addition, Zn-BTC also displayed the ability of lowering the expression of antioxidant genes: superoxide dismutase 1, superoxide dismutase 2 and interleukin 6, and enhancing the expression of wound healing genes: transforming growth factors-beta and type I collagen. Finally, it also demonstrated that Zn-BTC could effectively improve the skin wound healing of SD rats and had no toxicity on major organs. The favorable biocompatibility, antibacterial and anti-inflammatory properties of Zn-BTC gave a new insight of designing novel MOFs for promoting skin wound healing.
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页数：12
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