Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain

被引：20

作者：

Adachi, Masaatsu ^{[1
]}

Higuchi, Keiko ^{[1
]}

Thasana, Nopporn ^{[2
]}

Yamada, Hitomi ^{[1
]}

Nishikawa, Toshio ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Chulabhorn Res Inst, Med Chem Lab, Bangkok 10210, Thailand

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

LIPID DROPLET SYNTHESIS; ORGANOSTANNANES; INHIBITOR;

D O I：

10.1021/ol202895u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two possible diastereomers of the indole moiety of sespendole were synthesized from 3-hydroxy-4-nitrobenzaldehyde in a highly stereoselective manner. Comparison of H-1 and C-13 NMR spectra of the two synthetic materials with those sespendole leads us to propose that the relative stereochemistry of the epoxyalcohol is syn.

引用

页码：114 / 117

页数：4

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