Acridones as inducers of HL-60 cell differentiation

被引：37
|
作者：
Kawaii, S
Tomono, Y
Katase, E
Ogawa, K
Yano, M [1 ]
Takemura, Y
Ju-Ichi, M
Ito, C
Furukawa, H
机构：
[1] Natl Inst Fruit Tree Sci, Shizuoka 4240204, Japan
[2] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
[3] Meiji Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan
来源：
LEUKEMIA RESEARCH | 1999年 / 23卷 / 03期
关键词：
acridones; atalaphyllinine; atalaphyllidine; des-N-methylnoracronycine; differentiation; HL-60;
D O I：
10.1016/S0145-2126(98)00174-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fifteen acridone alkaloids were examined for their activity of induction of human promyelocytic leukemia cell (HL-60) differentiation. HL-60 cells were differentiated into mature monocyte/macrophage by atalaphyllidine (9), atalaphyllinine (12), and des-N-methylnoracronycine (13). The activities of NET reduction, nonspecific esterase, and phagocytosis, were induced by 2.5 mu M of 9, 12, and 13. After a 4-day treatment, 9, 12, and 13 at 10 mu M inhibited clonal proliferation of HL-60 cells by 28, 96, and 63%, respectively. The structure-activity relationship established from the results revealed that hydroxyl group at C-1 and prenyl group at C-2 had an important role. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：263 / 269
页数：7
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