Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept

被引：56
作者：
Gomes, Pedro Sa [1 ]
Rodrigues, Alirio E. [1 ]
机构：
[1] Univ Porto, Fac Engn, Dept Engn Quim, LSRE,Associate Lab LSRE LCM, P-4200465 Oporto, Portugal
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2012年 / 35卷 / 01期
关键词：
Chiral resolution; Chiralpak (R) AD; Continuous chromatographic processes; Countercurrent moving bed chromatography; Enantiomer separation; Simulated moving bed; True moving bed; COUNTERCURRENT ADSORPTION SEPARATION; MULTICOMPONENT ION EXCHANGE; P-XYLENE SEPARATION; INHALATION ANESTHETIC ENFLURANE; GRADIENT PURIFICATION MCSGP; GLUCOSE-FRUCTOSE SEPARATION; REDUCED PURITY REQUIREMENTS; TROGERS BASE ENANTIOMERS; MASS-TRANSFER RESISTANCE; LINEAR ISOTHERM SYSTEMS;
D O I：
10.1002/ceat.201100281
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE (R) unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration.
引用
收藏
页码：17 / 34
页数：18
相关论文
共 226 条
[41]   Simulated moving bed chromatographic resolution of a chiral antitussive [J].
Francotte, E ;
Richert, P ;
Mazzotti, M ;
Morbidelli, M .
JOURNAL OF CHROMATOGRAPHY A, 1998, 796 (02) :239-248
[42]   Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers [J].
Francotte, ER .
JOURNAL OF CHROMATOGRAPHY A, 2001, 906 (1-2) :379-397
[43]  
Francotte ER, 1997, J CHROMATOGR A, V769, P1
[44]   Conceptual design and feasibility study of combining continuous chromatography and crystallization for stereoisomer separations [J].
Gedicke, K. ;
Kaspereit, M. ;
Beckmann, W. ;
Budde, U. ;
Lorenz, H. ;
Seidel-Morgenstern, A. .
CHEMICAL ENGINEERING RESEARCH & DESIGN, 2007, 85 (A7) :928-936
[45]  
Geier D., 2010, US Patent, Patent No. [7828978, US 7 828 978]
[46]  
Geier D. F., 2010, US Patent, Patent No. [7705170, US 7 705 170]
[47]  
Gembicki S. A., 2002, KIRKOTHMERS ENCY SEP
[48]   THEORY OF CHROMATOGRAPHY .10. FORMULAE FOR DIFFUSION INTO SPHERES AND THEIR APPLICATION TO CHROMATOGRAPHY [J].
GLUECKAUF, E .
TRANSACTIONS OF THE FARADAY SOCIETY, 1955, 51 (11) :1540-1551
[49]  
Gomes P. Sa, 2009, THESIS U PORTO
[50]   Operation of an industrial SMB unit for p-xylene separation accounting for adsorbent ageing problems [J].
Gomes, Pedro Sa ;
Minceva, Mirjana ;
Rodrigues, Alirio E. .
SEPARATION SCIENCE AND TECHNOLOGY, 2008, 43 (08) :1974-2002
12345678910