Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept

被引：56
作者：
Gomes, Pedro Sa [1 ]
Rodrigues, Alirio E. [1 ]
机构：
[1] Univ Porto, Fac Engn, Dept Engn Quim, LSRE,Associate Lab LSRE LCM, P-4200465 Oporto, Portugal
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2012年 / 35卷 / 01期
关键词：
Chiral resolution; Chiralpak (R) AD; Continuous chromatographic processes; Countercurrent moving bed chromatography; Enantiomer separation; Simulated moving bed; True moving bed; COUNTERCURRENT ADSORPTION SEPARATION; MULTICOMPONENT ION EXCHANGE; P-XYLENE SEPARATION; INHALATION ANESTHETIC ENFLURANE; GRADIENT PURIFICATION MCSGP; GLUCOSE-FRUCTOSE SEPARATION; REDUCED PURITY REQUIREMENTS; TROGERS BASE ENANTIOMERS; MASS-TRANSFER RESISTANCE; LINEAR ISOTHERM SYSTEMS;
D O I：
10.1002/ceat.201100281
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE (R) unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration.
引用
收藏
页码：17 / 34
页数：18
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