Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress

被引:47
作者
Jiang, Baohong [1 ]
Zhang, Lin [1 ]
Li, Ming [1 ]
Wu, Wanying [1 ]
Yang, Min [1 ]
Wang, Junchen [2 ]
Guo, De-an [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
[2] Tongji Univ, Dongfang Hosp, Dept Pathol, Shanghai 200120, Peoples R China
关键词
salvianolic acids; doxorubicin; cardioprotection; free radical;
D O I
10.1016/j.fct.2007.12.020
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Although doxorubicin is an effective antitumor agent, the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. In China, salvianolic acids has been widely used for cardioprotection. To test whether salvianolic acids holds the potential to be protective against cardiotoxicity of doxorubicin, we created an acute cardiac injury mice model. Therapeutic treatment with salvianolic acids (40 mg/kg for 3 connective days) significantly reduced doxorubicin-induced (15 mg/kg) toxicity, including elevation of body weight and heart weight/tibia length ratio, decrease of creatine kinase, improvement of electrocardiography and heart vacuolation. Furthermore, the antioxidative effects of salvianolic acids were verified by oxygen radicals absorbance capacities assay in vitro and malondialdehyde detection in vivo, suggesting one possible mechanism of salvianolic acids on cardioprotection through blocking oxidative stress. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1510 / 1515
页数:6
相关论文
共 22 条
[1]   Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions [J].
Adams J.D. ;
Wang R. ;
Yang J. ;
Lien E.J. .
Chinese Medicine, 1 (1)
[2]   Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats [J].
Anjos Ferreira, Ana Lucia ;
Favero Salvadori, Daisy Maria ;
Munhoz Oliveira Nascimento, Maria Carolina ;
Rocha, Noeme Souza ;
Correa, Camila R. ;
Pereira, Elenize Jamas ;
Matsubara, Luiz Shiguero ;
Matsubara, Beatriz Bojikian ;
Placido Ladeira, Marcelo Sady .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2007, 631 (01) :26-35
[3]  
Cao GH, 1999, METHOD ENZYMOL, V299, P50
[4]   Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta [J].
Chen, Yuh-Lien ;
Hu, Cing-Siang ;
Lin, Feng-Yen ;
Chen, Yung-Hsiang ;
Sheu, Li-Min ;
Ku, Hung-Hai ;
Shiao, Ming-Shi ;
Chen, Jaw-Wen ;
Lin, Shing-Jong .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (03) :618-631
[5]   Lecithinized copper,zinc-superoxide dismutase as a protector against doxorubicin-induced cardiotoxicity in mice [J].
den Hartog, GJM ;
Haenen, GRMM ;
Boven, E ;
van der Vijgh, WJF ;
Bast, A .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2004, 194 (02) :180-188
[6]   Magnetic resonance imaging accurately estimates LV mass in a transgenic mouse model of cardiac hypertrophy [J].
Franco, F ;
Dubois, SK ;
Peshock, RM ;
Shohet, RV .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 274 (02) :H679-H683
[7]   Losing heart: the role of apoptosis in heart disease - a novel therapeutic target? [J].
Gill, C ;
Mestril, R ;
Samali, A .
FASEB JOURNAL, 2002, 16 (02) :135-146
[8]   Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats [J].
Jang, YM ;
Kendaiah, S ;
Drew, B ;
Phillips, T ;
Selman, C ;
Julian, D ;
Leeuwenburgh, C .
FEBS LETTERS, 2004, 577 (03) :483-490
[9]   DNA damage is an early event in doxorubicin-induced cardiac myocyte death [J].
L'Ecuyer, Thomas ;
Sanjeev, Sanjeev ;
Thomas, Ronald ;
Novak, Raymond ;
Das, Lauri ;
Campbell, Wendy ;
Vander Heide, Richard .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (03) :H1273-H1280
[10]   Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels [J].
Lam, Francis F. Y. ;
Yeung, John H. K. ;
Kwan, Yiu W. ;
Chan, Kam M. ;
Or, Penelope M. Y. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 553 (1-3) :240-245