Synthesis of Quinoxaline Analogues

被引：11

作者：

Chang, Meng-Yang ^{[1
]}

Lee, Tein-Wei ^{[1
]}

Hsu, Ru-Ting ^{[2
]}

Yen, Tzu-Lin ^{[3
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

[2] ShuZen Coll Med & Management, Dept Nursing, Kaohsiung 821, Taiwan

[3] Kaohsiung Med Univ, Dept Nursing, Kaohsiung Municipal Hsiao Kang Hosp, Kaohsiung 807, Taiwan

来源：

SYNTHESIS-STUTTGART | 2011年 / 19期

关键词：

condensation; halogenation; tandem reactions; heterocycles; arenes; ALPHA-HYDROXY KETONES; SOLID-PHASE SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; MOLECULAR-IODINE; TANDEM OXIDATION; AMMONIUM-NITRATE; DERIVATIVES; DIHYDROPYRAZINES; CYCLIZATION;

D O I：

10.1055/s-0030-1260147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted tricyclic or tetracyclic quinoxalines, tricyclic pyridoquinoxalines and bis-quinoxalines were synthesized in high yields starting from cyclic ketones by the alpha-bromination of cyclic ketones with N-bromosuccinimide (NBS) followed by condensation of the resulting alpha-bromo ketones with 1,2-diaminobenzene, 3,4-diaminopyridine, or 3,3'-diaminobenzidine.

引用

页码：3143 / 3151

页数：9

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