Study of interleukin-6 and tumor necrosis factor-α levels in maternal serum and amniotic fluid of patients with premature rupture of membranes

被引:0
作者
Zhang, WY [1 ]
Wang, L
机构
[1] Bethune Univ Med Sci, Teaching Hosp 2, Dept Obstet & Gynecol, Changchun, Peoples R China
[2] 208th Hosp, Dept Obstet & Gynecol, Changchun 130062, Peoples R China
关键词
chorioamnionitis; IL-6; pregnancy; premature rupture of membrane; TNF-alpha;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To study the change and clinical significance of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels in the maternal serum and amniotic fluid of pregnant women with chorioamnionitis and with premature rupture of membranes. Twenty-six normal-term pregnant women formed the control group, and forty-six pregnant women with premature rupture of membranes were enrolled for the study. Maternal serum and amniotic fluid IL-6 and TNF-alpha levels were measured using a sensitive radioimmunoassay and enzyme-linked immunosorbent assay (ELISA); chorioamnionitis was diagnosed by fetal membrane pathology. The maternal serum IL-6 levels and amniotic fluid IL-6 and TNF-alpha levels were higher than those of the control (P < 0.01). There was a significant relationship between maternal serum IL-6 and maternal serum and amniotic fluid IL-6 and TNF-alpha with the lime of the premature rupture of membranes, i.e. the longer the time, the higher the maternal serum and amniotic fluid IL-6 and TNF-alpha. There were 12 patients with chorioamnionitis in premature rupture of membranes and their maternal serum and amniotic fluid IL-6 and TNF-alpha levels were higher than that of non-chorioamnionitis patients (P < 0.01 0.05). IL-6 and TNF-alpha levels in maternal and amniotic fluids are a valuable index in identification of the chorioamnionitis in patients with premature rupture of membranes.
引用
收藏
页码:491 / 494
页数:4
相关论文
共 8 条
  • [1] Fortunato SJ, 1996, AM J OBSTET GYNECOL, V174, P1855, DOI 10.1016/S0002-9378(96)70221-1
  • [2] Interleukin gene expression in mouse preimplantation development
    Gerwin, N
    Jia, GQ
    Kulbacki, R
    GutierrezRamos, JC
    [J]. DEVELOPMENTAL IMMUNOLOGY, 1995, 4 (03): : 169 - +
  • [3] THE VALUE OF AMNIOTIC-FLUID INTERLEUKIN-6, WHITE BLOOD-CELL COUNT, AND GRAM STAIN IN THE DIAGNOSIS OF MICROBIAL INVASION OF THE AMNIOTIC CAVITY IN PATIENTS AT TERM
    GOMEZ, R
    ROMERO, R
    GALASSO, M
    BEHNKE, E
    INSUNZA, A
    COTTON, DB
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1994, 32 (03): : 200 - 210
  • [4] MAMATA D, 1992, ENDOCRINOLOGY, V131, P14
  • [5] Maternal serum interleukin-6 concentrations in patients with preterm premature rupture of membranes and evidence of infection
    Murtha, AP
    Greig, PC
    Jimmerson, CE
    RoitmanJohnson, B
    Allen, J
    Herbert, WNP
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1996, 175 (04) : 966 - 969
  • [6] A COMPARATIVE-STUDY OF THE DIAGNOSTIC PERFORMANCE OF AMNIOTIC-FLUID GLUCOSE, WHITE BLOOD-CELL COUNT, INTERLEUKIN-6, AND GRAM STAIN IN THE DETECTION OF MICROBIAL INVASION IN PATIENTS WITH PRETERM PREMATURE RUPTURE OF MEMBRANES
    ROMERO, R
    YOON, BH
    MAZOR, M
    GOMEZ, R
    GONZALEZ, R
    DIAMOND, MP
    BAUMANN, P
    ARANEDA, H
    KENNEY, JS
    COTTON, DB
    SEHGAL, P
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (04) : 839 - 851
  • [7] STEVEN RI, 1994, AM J OBSTET GYNECOL, V171, P5
  • [8] AMNIOTIC-FLUID INTERLEUKIN-6 - A SENSITIVE TEST FOR ANTENATAL DIAGNOSIS OF ACUTE INFLAMMATORY LESIONS OF PRETERM PLACENTA AND PREDICTION OF PERINATAL MORBIDITY
    YOON, BH
    ROMERO, R
    KIM, CJ
    JUN, JK
    GOMEZ, R
    CHOI, JH
    SYN, HC
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 172 (03) : 960 - 970