Palladium(II)-Catalyzed Asymmetric Tandem Cyclization of 2-Aminoaryl Alkynones: An Approach to Chiral 1,2,3,4-Tetrahydro-β-carbolines

被引：28

作者：

Chen, Junjie ^{[1
]}

Han, Xiuling ^{[1
]}

Lu, Xiyan ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 23期

基金：

中国国家自然科学基金;

关键词：

TETRAHYDRO-BETA-CARBOLINES; PICTET-SPENGLER REACTION; TRANSFER HYDROGENATION; CYCLIC IMINES; ACID; DERIVATIVES; STEREOSELECTIVITY; CONSTRUCTION; BENZOQUINONE; ELIMINATION;

D O I：

10.1021/acs.orglett.8b03247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd(OAc)(2)-catalyzed asymmetric cyclization of 2-aminoaryl alkynones involving an intramolecular trans-aminopalladation of alkyne and 1,2-addition to the carbonyl group tandem processes was developed. This strategy represents the first example using palladium as the catalyst and 2-alkynylaniline derivatives as the starting material to allow facile access to chiral 1,2,3,4-tetrahydro-beta-carbolines in high yields and excellent enantioselectivities.

引用

页码：7470 / 7473

页数：4

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