Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors

被引：15

作者：

Dygai, A. M. ^{[1
]}

Zyuz'kov, G. N. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Udut, E. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Khrichkova, T. Yu ^{[1
]}

Simanina, E. V. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Chaikovskiy, A. V. ^{[1
]}

Markova, T. S. ^{[1
]}

Minakova, M. Yu ^{[1
]}

Gol'dberg, V. E.

Artamonov, A. V. ^{[2
]}

Bekarev, A. A. ^{[2
]}

Madonov, P. G. ^{[2
]}

Kinsht, D. N. ^{[2
]}

Gurto, R. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Pharmacol, Siberian branch, Tomsk, Russia

[2] Sci Future Management Ltd, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 01期

关键词：

immobilized hyaluronidase; cytokines; progenitor cells; drugs; nanotechnology;

D O I：

10.1007/s10517-011-1277-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In vitro experiments demonstrated increased colony-forming capacity of erythroid, granulomonocytic, and mesenchymal progenitors of the bone marrow and parenchymal progenitor elements of the liver after treatment with immobilized hyaluronidase. Increased sensitivity of these progenitor cells to erythropoietin, granulocyte colony-stimulating factor, fibroblast growth factor, and stem cell factor, respectively, was demonstrated. Immobilized hyaluronidase enhanced the formation of tissue-specific hepatic CFU against the background of reduced yield of stromal precursors in liver tissue culture containing insulin.

引用

页码：150 / 153

页数：4

共 15 条

[1] ALLERGIC REACTIONS TO DRUGS AND BIOLOGICAL AGENTS [J].

ANDERSON, JA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 268 (20) :2845-2857

[2]

[Anonymous], SYSTEM CYTOKINES THE

[3]

Dygai A. M., 2009, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, P6

[4]

Dygai A. M., 2009, KLETOCHN TEKHNOL BIO, P63

[5]

Dygai A. M., 2009, SCI RUSSIA, V169, P4

[6]

Dygai A. M., 2010, B EKSP BIOL MED, V149, P528

[7]

EPSTEIN OI, 2005, KLETOCHN TEKHNOL BIO, P194

[8] Effects of granulocyte colony-stimulating factor and hyaluronidase on the formation of blood system reactions [J].

Goldberg, E. D. ;

Dygai, A. M. ;

Zyuz'kov, G. N. ;

Zhdanov, V. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 145 (06) :682-687

[9]

Goldberg E. D., 1992, METHODS TISSUE CULTU

[10]

Goldberg E. D., 2007, B EKSP BIOL MED, V144, P652

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