Applications of microarrays to histopathology

被引：55

作者：

van de Rijn, M

Gilks, CB

机构：

[1] Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA

[2] Vancouver Gen Hosp, British Columbia Canc Agcy, Dept Pathol, Genet Pathol Evaluat Ctr, Vancouver, BC, Canada

[3] Vancouver Gen Hosp, British Columbia Canc Agcy, Prostate Ctr, Vancouver, BC, Canada

[4] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

来源：

HISTOPATHOLOGY | 2004年 / 44卷 / 02期

关键词：

gene arrays; in situ hybridization; tissue microarrays;

D O I：

10.1111/j.1365-2559.2004.01766.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

High-throughput microarray technologies have the potential to impact significantly on the practice of histopathology over the coming years. Global gene expression profiling allows for a systematic search of all human genes for novel diagnostic and prognostic markers and for potential therapeutic targets. Likewise, gene copy number changes can be determined on a gene-by-gene basis using microarrays. Tissue microarrays are an efficient method to extend and validate the findings obtained from the initial 'discovery' phase of the research, done using cDNA microarrays. In addition, tissue microarrays can be used for quality assurance for immunohistochemical and in situ hybridization procedures. In this review we give a brief overview of microarray technology and research uses, and discuss potential applications of microarrays in the practice of diagnostic histopathology.

引用

页码：97 / 108

页数：12

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