Rational Design of ZIF-8 for Constructing Luminescent Biosensors with Glucose Oxidase and AIE-Type Gold Nanoclusters

被引：64

作者：

Sun, Yanping ^{[1
,2
]}

Shu, Tong ^{[1
]}

Ma, Jianxin ^{[1
,2
]}

Dai, Qiong ^{[1
]}

Peng, Peiwen ^{[1
]}

Zhou, Ziping ^{[1
,2
]}

Zhou, Xiang ^{[1
]}

Su, Lei ^{[1
]}

Zhang, Xueji ^{[1
]}

机构：

[1] Shenzhen Univ, Res Ctr Biosensor & Nanotheranost, Int Hlth Sci Innovat Ctr,Shenzhen Key Lab Nanobio, Hlth Sci Ctr,Sch Biomed Engn,Guangdong Lab Artifi, Shenzhen 518060, Guangdong, Peoples R China

[2] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Beijing 100083, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 07期

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC FRAMEWORKS; AGGREGATION-INDUCED EMISSION; ONE-POT SYNTHESIS; NANOPARTICLES; ENCAPSULATION; ENZYME;

D O I：

10.1021/acs.analchem.1c05599

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The development of modern technologies has acclimatized biosensors to complicated applicable scenarios with integrated properties as a whole instead of the pursuit of a single-point breakthrough. Here, we targeted a few concerns in the development of enzyme-based biosensors, including stability, analyte enrichment, and signal transduction, and developed a general biosensing model utilizing enzymes, aggregation-induced emission (AIE) luminogens, and stimuli-responsive framework materials as the units. We propose such proof-of-concept of glucose biosensors by coencapsulating glucose oxidase and AIE-type gold nanoclusters into acid-sensitive zeolite imidazolate framework (ZIF)-8 nanocrystals. The acid-activated degradation of ZIF-8 bridges the molecular signals produced by the enzyme-catalytic reaction of glucose and the photon signals generated by ZIF-8-induced AIE effects of gold nanoclusters, resulting in the "turn-off" model nanoprobes for glucose detection with high selectivity. After embedding the nanoprobes into hollow-out tapes, the formed paper biosensors can conveniently detect glucose with the help of a smartphone.

引用

页码：3408 / 3417

页数：10

共 58 条

[11] Biosensor developments: application to prostate-specific antigen detection [J].