The triad psoriasis-obesity-adipokine profile

被引：40

作者：

Coimbra, S. ^{[1
,2
]}

Catarino, C. ^{[1
]}

Santos-Silva, A. ^{[1
]}

机构：

[1] Univ Porto, Fac Farm, Lab Bioquim, Dept Ciencias Biol,UCIBIO REQUIMTE, Oporto, Portugal

[2] Inst Invest & Formacao Avancada Ciencias & Tecnol, CESPU, Grd Paredes, Portugal

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2016年 / 30卷 / 11期

关键词：

BODY-MASS INDEX; NECROSIS-FACTOR-ALPHA; RETINOL-BINDING PROTEIN-4; ENDOTHELIAL GROWTH-FACTOR; SERUM-LEVELS; TNF-ALPHA; INSULIN-RESISTANCE; ADIPOSE-TISSUE; ADIPONECTIN LEVELS; METABOLIC SYNDROME;

D O I：

10.1111/jdv.13701

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment. In this review, we will debate published data concerning the current knowledge about the triad psoriasis-obesity-adipokine profile.

引用

页码：1876 / 1885

页数：10

共 117 条

[21]

Cassano N, 2008, J BIOL REG HOMEOS AG, V22, P233

[22] Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans [J].

Catalan, V. ;

Gomez-Ambrosi, J. ;

Rodriguez, A. ;

Ramirez, B. ;

Silva, C. ;

Rotellar, F. ;

Gil, M. J. ;

Cienfuegos, J. A. ;

Salvador, J. ;

Fruhbeck, G. .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2009, 87 (08) :803-813

[23] Serum leptin levels, skin leptin and leptin receptor expression in psoriasis [J].

Cerman, A. A. ;

Bozkurt, S. ;

Sav, A. ;

Tulunay, A. ;

Elbasi, M. O. ;

Ergun, T. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (04) :820-826

[24] Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions [J].

Cesari, Matteo ;

Pahor, Marco ;

Incalzi, Raffaele Antonelli .

CARDIOVASCULAR THERAPEUTICS, 2010, 28 (05) :e72-e91

[25] Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review [J].

Chang, Yu-Hung ;

Chang, Dao-Ming ;

Lin, Kun-Cheng ;

Shin, Shyi-Jang ;

Lee, Yau-Jiunn .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2011, 27 (06) :515-527

[26] Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results From Two Prospective Cohorts [J].

Chen, Brian H. ;

Song, Yiqing ;

Ding, Eric L. ;

Roberts, Christian K. ;

Manson, Joann E. ;

Rifai, Nader ;

Buring, Julie E. ;

Gaziano, J. Michael ;

Liu, Simin .

DIABETES CARE, 2009, 32 (02) :329-334

[27]

Chen YJ, 2008, ARCH DERMATOL, V144, P1571, DOI 10.1001/archderm.144.12.1571

[28]

Chodorowska G, 2001, Ann Univ Mariae Curie Sklodowska Med, V56, P165

[29] How TNF was recognized as a key mechanism of disease [J].

Clark, Ian A. .

CYTOKINE & GROWTH FACTOR REVIEWS, 2007, 18 (3-4) :335-343

[30] The effect of weight on the efficacy of biologic therapy in patients with psoriasis [J].

Clark, Lily ;

Lebwohl, Mark .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (03) :443-446

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