Inhibitors of the ras signal transduction pathway as potential antitumour agents

被引：8
作者：
Perrin, D [1 ]
Halazy, S [1 ]
Hill, BT [1 ]
机构：
[1] CTR RECH PIERRE FABRE,DIV CANCEROL EXPT,F-81106 CASTRES,FRANCE
来源：
JOURNAL OF ENZYME INHIBITION | 1996年 / 11卷 / 02期
关键词：
Ras; farnesyl-protein transferase; Ras signalling pathway; farnesyl-protein transferase inhibitors; antitumour activity; Ras processing;
D O I：
10.3109/14756369609036536
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：77 / 95
页数：19
相关论文
共 105 条
[71]  
NAGASU T, 1995, CANCER RES, V55, P5310
[72]  
NAKANISHI M, 1988, J BIOL CHEM, V263, P8929
[73]   PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .1. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY [J].
OMURA, S ;
VANDERPYL, D ;
INOKOSHI, J ;
TAKAHASHI, Y ;
TAKESHIMA, H .
JOURNAL OF ANTIBIOTICS, 1993, 46 (02) :222-228
[74]   PHOSPHINYL ACID-BASED BISUBSTRATE ANALOG INHIBITORS OF RAS FARNESYL-PROTEIN TRANSFERASE [J].
PATEL, DV ;
GORDON, EM ;
SCHMIDT, RJ ;
WELLER, HN ;
YOUNG, MG ;
ZAHLER, R ;
BARBACID, M ;
CARBONI, JM ;
GULLOBROWN, JL ;
HUNIHAN, L ;
RICCA, C ;
ROBINSON, S ;
SEIZINGER, BR ;
TUOMARI, AV ;
MANNE, V .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (03) :435-442
[75]   SCH-58450, A NOVEL FARNESYL-PROTEIN TRANSFERASE INHIBITOR POSSESSING A 6A,12A-7,12-DIEPOXYBENZ[A]ANTHRACENE RING-SYSTEM [J].
PHIFE, DW ;
PATTON, RW ;
BERRIE, RL ;
YARBOROUGH, R ;
PUAR, MS ;
PATEL, M ;
BISHOP, WR ;
COVAL, SJ .
TETRAHEDRON LETTERS, 1995, 36 (39) :6995-6998
[76]  
PRENDERGAST GC, 1995, ONCOGENE, V10, P2289
[77]   FARNESYLTRANSFERASE INHIBITION CAUSES MORPHOLOGICAL REVERSION OF RAS-TRANSFORMED CELLS BY A COMPLEX MECHANISM THAT INVOLVES REGULATION OF THE ACTIN CYTOSKELETON [J].
PRENDERGAST, GC ;
DAVIDE, JP ;
DESOLMS, SJ ;
GIULIANI, EA ;
GRAHAM, SL ;
GIBBS, JB ;
OLIFF, A ;
KOHL, NE .
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) :4193-4202
[78]   AN ESSENTIAL ROLE FOR RAC IN RAS TRANSFORMATION [J].
QIU, RG ;
CHEN, J ;
KIRN, D ;
MCCORMICK, F ;
SYMONS, M .
NATURE, 1995, 374 (6521) :457-459
[79]   A ROLE FOR RHO IN RAS TRANSFORMATION [J].
QIU, RG ;
CHEN, J ;
MCCORMICK, F ;
SYMONS, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11781-11785
[80]   MASSIVE PROGRAMMED CELL-DEATH IN INTESTINAL EPITHELIAL-CELLS INDUCED BY 3-DIMENSIONAL GROWTH-CONDITIONS - SUPPRESSION BY MUTANT C-H-RAS ONCOGENE EXPRESSION [J].
RAK, J ;
MITSUHASHI, Y ;
ERDOS, V ;
HUANG, SN ;
FILMUS, J ;
KERBEL, RS .
JOURNAL OF CELL BIOLOGY, 1995, 131 (06) :1587-1598
234567891011