Inhibitors of the ras signal transduction pathway as potential antitumour agents

被引:8
作者
Perrin, D [1 ]
Halazy, S [1 ]
Hill, BT [1 ]
机构
[1] CTR RECH PIERRE FABRE,DIV CANCEROL EXPT,F-81106 CASTRES,FRANCE
来源
JOURNAL OF ENZYME INHIBITION | 1996年 / 11卷 / 02期
关键词
Ras; farnesyl-protein transferase; Ras signalling pathway; farnesyl-protein transferase inhibitors; antitumour activity; Ras processing;
D O I
10.3109/14756369609036536
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:77 / 95
页数:19
相关论文
共 105 条
[51]  
LEBOWITZ PF, 1995, MOL CELL BIOL, V15, P6613
[52]   Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity [J].
Leftheris, K ;
Kline, T ;
Vite, GD ;
Cho, YH ;
Bhide, RS ;
Patel, DV ;
Patel, MM ;
Schmidt, RJ ;
Weller, HN ;
Andahazy, ML ;
Carboni, JM ;
GulloBrown, JL ;
Lee, FYF ;
Ricca, C ;
Rose, WC ;
Yan, N ;
Barbacid, M ;
Hunt, JT ;
Meyers, CA ;
Seizinger, BR ;
Zahler, R ;
Manne, V .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) :224-236
[53]  
LEONARD S, 1990, J BIOL CHEM, V265, P5157
[54]   RAS CAAX PEPTIDOMIMETIC FTI-277 SELECTIVELY BLOCKS ONCOGENIC RAS SIGNALING BY INDUCING CYTOPLASMIC ACCUMULATION OF INACTIVE RAS-RAF COMPLEXES [J].
LERNER, EC ;
QIAN, YM ;
BLASKOVICH, MA ;
FOSSUM, RD ;
VOGT, A ;
SUN, JZ ;
COX, AD ;
DER, CJ ;
HAMILTON, AD ;
SEBTI, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26802-26806
[55]   DISRUPTION OF ONCOGENIC K-RAS4B PROCESSING AND SIGNALING BY A POTENT GERANYLGERANYLTRANSFERASE-I INHIBITOR [J].
LERNER, EC ;
QIAN, YM ;
HAMILTON, AD ;
SEBTI, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26770-26773
[56]  
LINGHAM RB, 1993, APPL MICROBIOL BIOT, V40, P370
[57]   DIFFERENTIATION OF CULTURED HUMAN-MELANOMA CELLS INDUCED BY THE AROMATIC FATTY-ACIDS PHENYLACETATE AND PHENYLBUTYRATE [J].
LIU, L ;
SHACK, S ;
STETLERSTEVENSON, WG ;
HUDGINS, WR ;
SAMID, D .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (03) :335-340
[58]   INHIBITORS OF THE ISOPRENYLATED PROTEIN ENDOPROTEASE [J].
MA, YT ;
GILBERT, BA ;
RANDO, RR .
BIOCHEMISTRY, 1993, 32 (09) :2386-2393
[59]   POSTTRANSLATIONAL MODIFICATION OF PROTEINS BY ISOPRENOIDS IN MAMMALIAN-CELLS [J].
MALTESE, WA .
FASEB JOURNAL, 1990, 4 (15) :3319-3328
[60]  
MANNE V, 1995, ONCOGENE, V10, P1763