The spatial relation of diabetic retinal neurodegeneration with diabetic retinopathy

被引:19
作者
van de Kreeke, Jacoba A. [1 ]
Darma, Stanley [2 ]
Yin, Jill M. P. L. Chan Pin [1 ]
Tan, H. Stevie [1 ,2 ]
Abramoff, Michael D. [3 ,4 ,5 ]
Twisk, Jos W. R. [6 ]
Verbraak, Frank D. [1 ,2 ]
机构
[1] Amsterdam UMC, Dept Ophthalmol, Locat VUmc, Amsterdam, Netherlands
[2] Amsterdam UMC, Dept Ophthalmol, Locat AMC, Amsterdam, Netherlands
[3] Univ Iowa Hosp & Clin, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA
[4] VA Med Ctr, Iowa City, IA USA
[5] IDx, Iowa City, IA USA
[6] Amsterdam UMC, Dept Epidemiol & Biostat, Locat VUmc, Amsterdam, Netherlands
来源
PLOS ONE | 2020年 / 15卷 / 04期
基金
美国国家卫生研究院;
关键词
OPTICAL COHERENCE TOMOGRAPHY; CELL LAYER THICKNESS; MELLITUS TYPE-1; MACULAR EDEMA; EYES; AGE;
D O I
10.1371/journal.pone.0231552
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose Diabetic retinal neurodegeneration (DRN) has been demonstrated in eyes of patients with diabetes mellitus (DM), even in the absence of diabetic retinopathy (DR). However, no studies have looked at the rate of change in retinal layers and presence/development of DR over time per quadrant of the macula. In this longitudinal study, we aimed to clarify whether the rate of DRN is associated with the development/presence of DR within 4 different quadrants of the retina. Methods 80 eyes of 40 patients with type 1 DM and no/minimal DR were included. At 4 visits over 6 years, SD-OCT and fundus images were acquired. Thickness of the Retinal Nerve Fiber Layer (RNFL), Ganglion Cell Layer (GCL) and Inner Plexiform Layer (IPL) was measured in a 1-6mm circle around the fovea overall and for each quadrant (superior, nasal, inferior, temporal). Fundus images were scored for the presence/absence of DR in these areas. Multilevel analyses were performed to determine the rate of change for each layer overall and per quadrant for eyes/quadrants without and with DR during the follow-up period. Results RNFL and GCL showed significant thinning over time, IPL significant thickening. These changes were more pronounced for GCL and IPL in eyes/quadrants with DR during the follow-up period. Conclusions RNFL and GCL both showed thinning over time, which was more pronounced in eyes with DR for GCL. This holds true even in regional parts of the retina, as quadrant analyses showed similar results, showing that structural DRN is associated with DR per quadrant independently.
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页数:10
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