Cannabis use and brain structural alterations in first episode schizophrenia - A region of interest, voxel based morphometric study
被引:71
作者:
Bangalore, Srihari S.
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机构:
UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Bangalore, Srihari S.
[1
]
Prasad, Konasale M. R.
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机构:
UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Prasad, Konasale M. R.
[1
]
Montrose, Debra M.
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UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Montrose, Debra M.
[1
]
Goradia, Dhruman D.
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UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Goradia, Dhruman D.
[1
]
Diwadkar, Vaibhav A.
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UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Wayne State Univ, Sch Med, Detroit, MI 48201 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Diwadkar, Vaibhav A.
[1
,2
]
Keshavan, Matcheri S.
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机构:
UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Wayne State Univ, Sch Med, Detroit, MI 48201 USAUPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
Keshavan, Matcheri S.
[1
,2
]
机构:
[1] UPMC, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA
[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA
schizophrenia;
cannabis;
voxel based morphometry;
magnetic resonance imaging;
posterior cingulate;
D O I:
10.1016/j.schres.2007.11.029
中图分类号:
R749 [精神病学];
学科分类号:
100205 ;
摘要:
Structural alterations of the brain in schizophrenia have been associated with genetic and environmental factors. Among the environmental factors, cannabis use has been associated with increased risk for patients with schizophrenia, but the effect of cannabis on their brain structure is unclear. We examined gray matter alterations in first episode schizophrenia patients (FES) with cannabis use (FES + C; n = 15) compared to FES without cannabis use (FES - C; n = 24) and 42 healthy controls who did not use cannabis. We conducted a voxel based morphometric analysis of a priori determined regions of interest consisting of the CB I receptor rich brain regions. We observed a decrease in gray matter density in the right posterior cingulate cortex (PCC) in FES + C when compared with FES-C. The results suggest that cannabis use may be associated with altered brain structure, in particular regions rich in CB I receptors. These findings need to be confirmed by larger, prospective studies. (C) 2007 Published by Elsevier B.V.