Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells

被引：5
|
作者：
Sek, Kevin [1 ,2 ]
Chan, Cheok Weng [1 ,2 ]
Beavis, Paul A. [1 ,2 ]
Darcy, Phillip K. [1 ,2 ,3 ,4 ]
机构：
[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3000, Australia
[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia
[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
[4] Monash Univ, Dept Immunol, Clayton, Vic, Australia
来源：
CANCER CELL | 2021年 / 39卷 / 12期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
CAR-T CELLS;
D O I：
10.1016/j.ccell.2021.10.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFN alpha/beta production.
引用
收藏
页码：1564 / 1566
页数：3
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