Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells

被引：5

作者：

Sek, Kevin ^{[1
,2
]}

Chan, Cheok Weng ^{[1
,2
]}

Beavis, Paul A. ^{[1
,2
]}

Darcy, Phillip K. ^{[1
,2
,3
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia

[4] Monash Univ, Dept Immunol, Clayton, Vic, Australia

来源：

CANCER CELL | 2021年 / 39卷 / 12期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

CAR-T CELLS;

D O I：

10.1016/j.ccell.2021.10.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFN alpha/beta production.

引用

页码：1564 / 1566

页数：3

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